Degradation of neutrophil extracellular traps co-varies with disease activity in patients with systemic lupus erythematosus

Table 2 ACR classification criteria for patients with normal and decreased ability to degrade NETs

ACR classification criteria	Normal (n= 41) number (%)	Decreased at least once (n= 28) number (%)	P-value (Pearson)
Malar rash	27 (66%)	19 (68%)	0.86
Discoid rash	12 (30%)	6 (21%)	0.47
Photosensitivity	30 (73%)	12 (43%)	0.01*
Oral ulcer	8 (20%)	8 (29%)	0.38
Arthritis	32 (78%)	23 (82%)	0.68
Serositis	18 (44%)	17 (61%)	0.17
Nephritis	19 (46%)	16 (57%)	0.38
Neurological disorder	2 (5%)	1 (4%)	0.79
Hematological disorder	21 (51%)	17 (61%)	0.44
Immunological disorder	27 (66%)	26 (93%)	0.009*
*Anti-dsDNA*	22 (54%)	23 (82%)	0.01*
*Anti-Sm*	4 (10%)	3 (11%)	0.90
*False positive Wasserman*	5 (12%)	1 (4%)	0.21
Anti-nuclear antibodies	41 (100%)	28 (100%)	-

American College of Rheumatology (ACR) classification criteria reflect the clinical history of systemic lupus erythematosus (SLE) and are compared for patients who always displayed normal ability to degrade neutrophil extracellular traps (NETs) compared to patients who at least once displayed a decreased ability to degrade NETs. Asterisks indicate significant differences with the increased proportion highlighted by bold numbers.

ISSN: 1478-6362