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Table 1 Characteristics of systemic sclerosis patients and controls at inclusion.

From: Ischemic arterial events and atherosclerosis in patients with systemic sclerosis: a population-based case-control study

  Patients (n= 111) Controls (n= 105) Pvalue
Age, years 61.8 ± 12.5 61.5 ± 12.3 ns
Gender female % (n) 81 (90) 86 (90) ns
Disease characteristics    
Disease duration (years) 9.4 (5.6-17.4) - -
Diffuse cutaneous % (n)
Limited cutaneous % (n)
22 (24)
78 (87)
-
-
-
Pulmonary fibrosis % (n) 46 (51) - -
Suspected pulmonary hypertension % (n) 15 (17) 0 -
Raynaud % (n) 95 (105) 11 (12) -
Digital ulcers ever % (n) 39 (43) 0 -
Calcinosis % (n) 27 (30) 0 -
Myositis % (n) 9 (10) 0 -
Arthritis % (n) 29 (32) 4 (4) -
Kidney involvement % (n) 7 (8) 0 -
Skin score 6 (3-10) 0 -
Disease activity 0.5 (0-2) - -
Disease severity 5 (3-6) - -
Autoantibodies
Anticentromere (ACA) % (n)
Antitopoisomerase 1 (ATA) % (n)
Antinuclear (ANA) neg % (n)
32 (35)
23 (25)
7 (8)
-
-
-
 
Traditional cardiovascular risk factors    
Body mass index (kg/m2) 24.2 ± 3.80 26.0 ± 3.7 0.0005
Waist-hip ratio 0.83 ± 0.09 0.84 ± 0.08 ns
Ever smoked % (n)
Current smoker % (n)
53 (59)
11 (12)
44 (46)
7 (7)
ns
ns
Systolic BP (mmHg)
Diastolic BP (mmHg)
Hypertension % (n)
123.18 ± 17.94
71.63 ± 10.65
30 (33)
124.09 ± 18.59
74.5 ± 9.49
20 (21)
ns
0.04
ns
P-glucose (mmol/l)
Diabetes % (n)
5.45 ± 1.17
6 (7)
5.43 ± 1.34
7 (7)
ns
ns
Cholesterol (mmol/l)
LDL (mmol/l)
HDL (mmol/l)
Triglycerides (mmol/l)
5.20 ± 1.04
3.32 ± 0.93
1.3 (1.0-1.5)
0.99 (0.76-1.5)
5.24 ± 1.15
3.37 ± 0.91
1.4 (1.2-1.7)
0.93 (0.67-1.3)
ns
ns
ns (0.09)
0.03
Inflammatory biomarkers    
hsCRP (mg/l) 2.2 (1.0-4.3) 1.75 (0.76-3.2) 0.05
Orosomucoid (g/l) 0.86 ± 0.23 0.77 ± 0.17 0.0009
Alpha1antitrypsine (g/l) 1.5 (1.4-1.6) 1.4 (1.2-1.5) <0.0001
Fibrinogen (g/l) 3.77 (3.3-4.34) 3.53 (2.80-4.25) 0.03
Sedimentation rate (mm)
Interleukin-6 (pg/ml)
14 (9-26)
29.9 (21.4-40.9)
10 (7-16.5)
27.1 (21.2-32.5)
0.002
ns (0.08)
Endothelial biomarkers    
VCAM-1 (ng/l) 698 (546-807) 531 (431-719) <0.0001
ICAM-1 (ng/l) 376 (314-472) 330 (254-450) 0.002
VEGF (pg/ml) 182 (143-258) 156 (103-239) 0.009
vWF (IU/ml) 1.25 (0.90-1.70) 0.85 (0.58-1.36) <0.0001
Renal function    
eGFR (mL/min/1.73 m2) 74 (50-116) 104 (89-126) 0.01
  1. Distributions are given as % (n), median (interquartile range) or mean ± standard deviation. BP, blood pressure; LDL, low-density lipoprotein; HDL, high-density lipoprotein; hsCRP, high-sensitivity C reactive protein; VCAM-1, vascular cell adhesion molecule 1; ICAM-1, intercellular adhesion molecule 1; VEGF, vascular endothelial growth factor; vWF, von Willebrand factor; eGFR, estimated glomerular filtration rate, based on cystatin C measurements.