Table 1 Characteristics of systemic sclerosis patients and controls at inclusion.
Patients (n= 111) | Controls (n= 105) | Pvalue | |
|---|---|---|---|
Age, years | 61.8 ± 12.5 | 61.5 ± 12.3 | ns |
Gender female % (n) | 81 (90) | 86 (90) | ns |
Disease characteristics | |||
Disease duration (years) | 9.4 (5.6-17.4) | - | - |
Diffuse cutaneous % (n) Limited cutaneous % (n) | 22 (24) 78 (87) | - - | - |
Pulmonary fibrosis % (n) | 46 (51) | - | - |
Suspected pulmonary hypertension % (n) | 15 (17) | 0 | - |
Raynaud % (n) | 95 (105) | 11 (12) | - |
Digital ulcers ever % (n) | 39 (43) | 0 | - |
Calcinosis % (n) | 27 (30) | 0 | - |
Myositis % (n) | 9 (10) | 0 | - |
Arthritis % (n) | 29 (32) | 4 (4) | - |
Kidney involvement % (n) | 7 (8) | 0 | - |
Skin score | 6 (3-10) | 0 | - |
Disease activity | 0.5 (0-2) | - | - |
Disease severity | 5 (3-6) | - | - |
Autoantibodies Anticentromere (ACA) % (n) Antitopoisomerase 1 (ATA) % (n) Antinuclear (ANA) neg % (n) | 32 (35) 23 (25) 7 (8) | - - - | |
Traditional cardiovascular risk factors | |||
Body mass index (kg/m2) | 24.2 ± 3.80 | 26.0 ± 3.7 | 0.0005 |
Waist-hip ratio | 0.83 ± 0.09 | 0.84 ± 0.08 | ns |
Ever smoked % (n) Current smoker % (n) | 53 (59) 11 (12) | 44 (46) 7 (7) | ns ns |
Systolic BP (mmHg) Diastolic BP (mmHg) Hypertension % (n) | 123.18 ± 17.94 71.63 ± 10.65 30 (33) | 124.09 ± 18.59 74.5 ± 9.49 20 (21) | ns 0.04 ns |
P-glucose (mmol/l) Diabetes % (n) | 5.45 ± 1.17 6 (7) | 5.43 ± 1.34 7 (7) | ns ns |
Cholesterol (mmol/l) LDL (mmol/l) HDL (mmol/l) Triglycerides (mmol/l) | 5.20 ± 1.04 3.32 ± 0.93 1.3 (1.0-1.5) 0.99 (0.76-1.5) | 5.24 ± 1.15 3.37 ± 0.91 1.4 (1.2-1.7) 0.93 (0.67-1.3) | ns ns ns (0.09) 0.03 |
Inflammatory biomarkers | |||
hsCRP (mg/l) | 2.2 (1.0-4.3) | 1.75 (0.76-3.2) | 0.05 |
Orosomucoid (g/l) | 0.86 ± 0.23 | 0.77 ± 0.17 | 0.0009 |
Alpha1antitrypsine (g/l) | 1.5 (1.4-1.6) | 1.4 (1.2-1.5) | <0.0001 |
Fibrinogen (g/l) | 3.77 (3.3-4.34) | 3.53 (2.80-4.25) | 0.03 |
Sedimentation rate (mm) Interleukin-6 (pg/ml) | 14 (9-26) 29.9 (21.4-40.9) | 10 (7-16.5) 27.1 (21.2-32.5) | 0.002 ns (0.08) |
Endothelial biomarkers | |||
VCAM-1 (ng/l) | 698 (546-807) | 531 (431-719) | <0.0001 |
ICAM-1 (ng/l) | 376 (314-472) | 330 (254-450) | 0.002 |
VEGF (pg/ml) | 182 (143-258) | 156 (103-239) | 0.009 |
vWF (IU/ml) | 1.25 (0.90-1.70) | 0.85 (0.58-1.36) | <0.0001 |
Renal function | |||
eGFR (mL/min/1.73 m2) | 74 (50-116) | 104 (89-126) | 0.01 |