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Table 3 Variables associated with ischemic arterial events in systemic sclerosis patients after age adjustment.

From: Ischemic arterial events and atherosclerosis in patients with systemic sclerosis: a population-based case-control study

  Any event (n= 20) IHD (n= 13) IPVD (n= 9)
  Odds ratio (95% CI) Pvalue Odds ratio (95% CI) Pvalue Odds ratio (95% CI) Pvalue
Age 1.10 (1.05-1.17) <0.0001 1.06 (1.01-1.13) 0.02 1.13 (1.05-1.26) 0.0005
Associations after adjustment for age
Kidney disease 8.8 (1.5-55.8) 0.01 6.6 (1.12-36.15) 0.04 ND 0.3
Skin score 1.13 (1.03-1.24) 0.008 1.07 (0.97-1.18) 0.1 1.16 (1.02-1.32) 0.02
Disease severity 1.29 (1.05-1.62) 0.02 1.11 (0.88-1.39) 0.4 1.15 (0.85-1.55) 0.3
ACA+ 3.61 (1.21-11.3) 0.02 1.9 (0.55-6.45) 0.2 6.8 (1.37-45.3) 0.02
ATA+ 0.18 (0.01-1.01) 0.05 0.00003 (0-0.6) 0.01 0.83 (0.04-5.67) 0.9
VCAM-1 5.30 (0.51-62.1) 0.2 27.3 (2.52-427. 4) 0.005 0.37 (0.02-5.46) 0.2
VEGF 0.68 (0.24-1.84) 0.4 0.29 (0.09-0.93) 0.03 0.52 (0.12-2.33) 0.4
eGFR 0.26 (0.10-0.62) 0.003 0.32 (0.12-0.81) 0.02 0.57 (0.15-3.65) 0.5
  1. IHD, ischemic heart disease; IPVD, ischemic peripheral vascular disease; CI, confidence interval; ACA, anticentromere antibody; +, positivity; ATA, antitopoisomerase 1 antibody; VCAM-1, vascular cell adhesion molecule 1; VEGF, vascular endothelial growth factor; eGFR, estimated glomerular filtration rate, based on cystatin C measurements.