TY - JOUR AU - Markway, Brandon D. AU - Cho, Holly AU - Johnstone, Brian PY - 2013 DA - 2013/08/21 TI - Hypoxia promotes redifferentiation and suppresses markers of hypertrophy and degeneration in both healthy and osteoarthritic chondrocytes JO - Arthritis Research & Therapy SP - R92 VL - 15 IS - 4 AB - Hypoxia is considered to be a positive influence on the healthy chondrocyte phenotype and cartilage matrix formation. However, hypoxia-inducible factors (HIFs) have been implicated in the pathogenesis of osteoarthritis (OA). Thus, we assessed whether healthy and OA chondrocytes have distinct responses to oxygen, particularly with regard to hypertrophy and degradation during redifferentiation. SN - 1478-6354 UR - https://doi.org/10.1186/ar4272 DO - 10.1186/ar4272 ID - Markway2013 ER -