TY - JOUR AU - Schiltz, J. R. AU - Mayne, R. AU - Holtzer, H. PY - 1973 DA - 1973// TI - The synthesis of collagen and glycosaminoglycans by dedifferentiated chondroblasts in culture JO - Differentiation VL - 1 UR - https://doi.org/10.1111/j.1432-0436.1973.tb00106.x DO - 10.1111/j.1432-0436.1973.tb00106.x ID - Schiltz1973 ER - TY - JOUR AU - Benya, P. D. AU - Shaffer, J. D. PY - 1982 DA - 1982// TI - Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels JO - Cell VL - 30 UR - https://doi.org/10.1016/0092-8674(82)90027-7 DO - 10.1016/0092-8674(82)90027-7 ID - Benya1982 ER - TY - JOUR AU - Dehne, T. AU - Karlsson, C. AU - Ringe, J. AU - Sittinger, M. AU - Lindahl, A. PY - 2009 DA - 2009// TI - Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation JO - Arthritis Res Ther VL - 11 UR - https://doi.org/10.1186/ar2800 DO - 10.1186/ar2800 ID - Dehne2009 ER - TY - JOUR AU - Tallheden, T. AU - Bengtsson, C. AU - Brantsing, C. AU - Sjögren-Jansson, E. AU - Carlsson, L. AU - Peterson, L. AU - Brittberg, M. AU - Lindahl, A. PY - 2005 DA - 2005// TI - Proliferation and differentiation potential of chondrocytes from osteoarthritic patients JO - Arthritis Res Ther VL - 7 UR - https://doi.org/10.1186/ar1709 DO - 10.1186/ar1709 ID - Tallheden2005 ER - TY - JOUR AU - Araldi, E. AU - Khatri, R. AU - Giaccia, A. J. AU - Simon, M. C. AU - Schipani, E. PY - 2011 DA - 2011// TI - Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development JO - Nat Med VL - 17 UR - https://doi.org/10.1038/nm0111-25 DO - 10.1038/nm0111-25 ID - Araldi2011 ER - TY - JOUR AU - Murphy, C. L. PY - 2010 DA - 2010// TI - HIF-2α: a mediator of osteoarthritis? JO - Cell Res VL - 20 UR - https://doi.org/10.1038/cr.2010.99 DO - 10.1038/cr.2010.99 ID - Murphy2010 ER - TY - JOUR AU - Nakajima, M. AU - Shi, D. AU - Dai, J. AU - Tsezou, A. AU - Zheng, M. AU - Norman, P. E. AU - Chou, C. H. AU - Lee, M. T. AU - Hwang, J. Y. AU - Kim, D. H. AU - Takahashi, A. AU - Ikegawa, S. AU - Jiang, Q. PY - 2012 DA - 2012// TI - A large-scale replication study for the association of rs17039192 in HIF-2α with knee osteoarthritis JO - J Orthop Res VL - 30 UR - https://doi.org/10.1002/jor.22063 DO - 10.1002/jor.22063 ID - Nakajima2012 ER - TY - JOUR AU - Lafont, J. E. AU - Talma, S. AU - Murphy, C. L. PY - 2007 DA - 2007// TI - Hypoxia-inducible factor 2α is essential for hypoxic induction of the human articular chondrocyte phenotype JO - Arthritis Rheum VL - 56 UR - https://doi.org/10.1002/art.22878 DO - 10.1002/art.22878 ID - Lafont2007 ER - TY - JOUR AU - Murphy, C. L. AU - Polak, J. M. PY - 2004 DA - 2004// TI - Control of human articular chondrocyte differentiation by reduced oxygen tension JO - J Cell Physiol VL - 199 UR - https://doi.org/10.1002/jcp.10481 DO - 10.1002/jcp.10481 ID - Murphy2004 ER - TY - JOUR AU - Thoms, B. L. AU - Dudek, K. A. AU - Lafont, J. E. AU - Murphy, C. L. PY - 2013 DA - 2013// TI - Hypoxia promotes the production and inhibits the destruction of human articular cartilage JO - Arthritis Rheum VL - 65 UR - https://doi.org/10.1002/art.37867 DO - 10.1002/art.37867 ID - Thoms2013 ER - TY - JOUR AU - Ströbel, S. AU - Loparic, M. AU - Wendt, D. AU - Schenk, A. D. AU - Candrian, C. AU - Lindberg, R. L. AU - Moldovan, F. AU - Barbero, A. AU - Martin, I. PY - 2010 DA - 2010// TI - Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages JO - Arthritis Res Ther VL - 12 UR - https://doi.org/10.1186/ar2942 DO - 10.1186/ar2942 ID - Ströbel2010 ER - TY - JOUR AU - Saito, T. AU - Fukai, A. AU - Mabuchi, A. AU - Ikeda, T. AU - Yano, F. AU - Ohba, S. AU - Nishida, N. AU - Akune, T. AU - Yoshimura, N. AU - Nakagawa, T. AU - Nakamura, K. AU - Tokunaga, K. AU - Chung, U. I. AU - Kawaguchi, H. PY - 2010 DA - 2010// TI - Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development JO - Nat Med VL - 16 UR - https://doi.org/10.1038/nm.2146 DO - 10.1038/nm.2146 ID - Saito2010 ER - TY - JOUR AU - Yang, S. AU - Kim, J. AU - Ryu, J. H. AU - Oh, H. AU - Chun, C. H. AU - Kim, B. J. AU - Min, B. H. AU - Chun, J. S. PY - 2010 DA - 2010// TI - Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction JO - Nat Med VL - 16 UR - https://doi.org/10.1038/nm.2153 DO - 10.1038/nm.2153 ID - Yang2010 ER - TY - JOUR AU - Bohensky, J. AU - Terkhorn, S. P. AU - Freeman, T. A. AU - Adams, C. S. AU - Garcia, J. A. AU - Shapiro, I. M. AU - Srinivas, V. PY - 2009 DA - 2009// TI - Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24444 DO - 10.1002/art.24444 ID - Bohensky2009 ER - TY - JOUR AU - Pfander, D. AU - Cramer, T. AU - Swoboda, B. PY - 2005 DA - 2005// TI - Hypoxia and HIF-1α in osteoarthritis JO - Int Orthop VL - 29 UR - https://doi.org/10.1007/s00264-004-0618-2 DO - 10.1007/s00264-004-0618-2 ID - Pfander2005 ER - TY - JOUR AU - Yudoh, K. AU - Nakamura, H. AU - Masuko-Hongo, K. AU - Kato, T. AU - Nishioka, K. PY - 2005 DA - 2005// TI - Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis JO - Arthritis Res Ther VL - 7 UR - https://doi.org/10.1186/ar1765 DO - 10.1186/ar1765 ID - Yudoh2005 ER - TY - JOUR AU - Husa, M. AU - Liu-Bryan, R. AU - Terkeltaub, R. PY - 2010 DA - 2010// TI - Shifting HIFs in osteoarthritis JO - Nat Med VL - 16 UR - https://doi.org/10.1038/nm0610-641 DO - 10.1038/nm0610-641 ID - Husa2010 ER - TY - JOUR AU - Ruiz-Romero, C. AU - Calamia, V. AU - Rocha, B. AU - Mateos, J. AU - Fernández-Puente, P. AU - Blanco, F. J. PY - 2010 DA - 2010// TI - Hypoxia conditions differentially modulate human normal and osteoarthritic chondrocyte proteomes JO - J Proteome Res VL - 9 UR - https://doi.org/10.1021/pr901209s DO - 10.1021/pr901209s ID - Ruiz-Romero2010 ER - TY - JOUR AU - Clérigues, V. AU - Murphy, C. L. AU - Guillén, M. I. AU - Alcaraz, M. J. PY - 2013 DA - 2013// TI - Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia JO - Clin Sci (Lond) VL - 125 UR - https://doi.org/10.1042/CS20120491 DO - 10.1042/CS20120491 ID - Clérigues2013 ER - TY - JOUR AU - Jakob, M. AU - Démarteau, O. AU - Schäfer, D. AU - Hintermann, B. AU - Dick, W. AU - Heberer, M. AU - Martin, I. PY - 2001 DA - 2001// TI - Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro JO - J Cell Biochem VL - 81 UR - https://doi.org/3.0.CO;2-J DO - 3.0.CO;2-J ID - Jakob2001 ER - TY - JOUR AU - Ball, S. T. AU - Amiel, D. AU - Williams, S. K. AU - Tontz, W. AU - Chen, A. C. AU - Sah, R. L. AU - Bugbee, W. D. PY - 2004 DA - 2004// TI - The effects of storage on fresh human osteochondral allografts JO - Clin Orthop Relat Res VL - 418 UR - https://doi.org/10.1097/00003086-200401000-00043 DO - 10.1097/00003086-200401000-00043 ID - Ball2004 ER - TY - JOUR AU - Angele, P. AU - Yoo, J. U. AU - Smith, C. AU - Mansour, J. AU - Jepsen, K. J. AU - Nerlich, M. AU - Johnstone, B. PY - 2003 DA - 2003// TI - Cyclic hydrostatic pressure enhances the chondrogenic phenotype of human mesenchymal progenitor cells differentiated in vitro JO - J Orthop Res VL - 21 UR - https://doi.org/10.1016/S0736-0266(02)00230-9 DO - 10.1016/S0736-0266(02)00230-9 ID - Angele2003 ER - TY - JOUR AU - Holden, P. AU - Horton, W. A. PY - 2009 DA - 2009// TI - Crude subcellular fractionation of cultured mammalian cell lines JO - BMC Res Notes VL - 2 UR - https://doi.org/10.1186/1756-0500-2-243 DO - 10.1186/1756-0500-2-243 ID - Holden2009 ER - TY - JOUR AU - Duval, E. AU - Leclercq, S. AU - Elissalde, J. M. AU - Demoor, M. AU - Galéra, P. AU - Boumédiene, K. PY - 2009 DA - 2009// TI - Hypoxia-inducible factor 1α inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1α-dependent redifferentiation of chondrocytes JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24851 DO - 10.1002/art.24851 ID - Duval2009 ER - TY - JOUR AU - Nishida, Y. AU - Knudson, C. B. AU - Nietfeld, J. J. AU - Margulis, A. AU - Knudson, W. PY - 1999 DA - 1999// TI - Antisense inhibition of hyaluronan synthase-2 in human articular chondrocytes inhibits proteoglycan retention and matrix assembly JO - J Biol Chem VL - 274 UR - https://doi.org/10.1074/jbc.274.31.21893 DO - 10.1074/jbc.274.31.21893 ID - Nishida1999 ER - TY - JOUR AU - Recklies, A. D. AU - White, C. AU - Melching, L. AU - Roughley, P. J. PY - 2001 DA - 2001// TI - Differential regulation and expression of hyaluronan synthases in human articular chondrocytes, synovial cells and osteosarcoma cells JO - Biochem J VL - 354 UR - https://doi.org/10.1042/bj3540017 DO - 10.1042/bj3540017 ID - Recklies2001 ER - TY - JOUR AU - Hashimoto, K. AU - Fukuda, K. AU - Yamazaki, K. AU - Yamamoto, N. AU - Matsushita, T. AU - Hayakawa, S. AU - Munakata, H. AU - Hamanishi, C. PY - 2006 DA - 2006// TI - Hypoxia-induced hyaluronan synthesis by articular chondrocytes: the role of nitric oxide JO - Inflamm Res VL - 55 UR - https://doi.org/10.1007/s00011-005-0012-6 DO - 10.1007/s00011-005-0012-6 ID - Hashimoto2006 ER - TY - JOUR AU - Yatabe, T. AU - Mochizuki, S. AU - Takizawa, M. AU - Chijiiwa, M. AU - Okada, A. AU - Kimura, T. AU - Fujita, Y. AU - Matsumoto, H. AU - Toyama, Y. AU - Okada, Y. PY - 2009 DA - 2009// TI - Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes JO - Ann Rheum Dis VL - 68 UR - https://doi.org/10.1136/ard.2007.086884 DO - 10.1136/ard.2007.086884 ID - Yatabe2009 ER - TY - JOUR AU - Julovi, S. M. AU - Ito, H. AU - Nishitani, K. AU - Jackson, C. J. AU - Nakamura, T. PY - 2011 DA - 2011// TI - Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38 JO - J Orthop Res VL - 29 UR - https://doi.org/10.1002/jor.21216 DO - 10.1002/jor.21216 ID - Julovi2011 ER - TY - JOUR AU - Schrobback, K. AU - Malda, J. AU - Crawford, R. W. AU - Upton, Z. AU - Leavesley, D. I. AU - Klein, T. J. PY - 2012 DA - 2012// TI - Effects of oxygen on zonal marker expression in human articular chondrocytes JO - Tissue Eng Part A VL - 18 UR - https://doi.org/10.1089/ten.tea.2011.0088 DO - 10.1089/ten.tea.2011.0088 ID - Schrobback2012 ER - TY - JOUR AU - Holmquist, L. AU - Jögi, A. AU - Påhlman, S. PY - 2005 DA - 2005// TI - Phenotypic persistence after reoxygenation of hypoxic neuroblastoma cells JO - Int J Cancer VL - 116 UR - https://doi.org/10.1002/ijc.21024 DO - 10.1002/ijc.21024 ID - Holmquist2005 ER - TY - JOUR AU - Richard, D. E. AU - Berra, E. AU - Gothié, E. AU - Roux, D. AU - Pouysségur, J. PY - 1999 DA - 1999// TI - p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1 JO - J Biol Chem VL - 274 UR - https://doi.org/10.1074/jbc.274.46.32631 DO - 10.1074/jbc.274.46.32631 ID - Richard1999 ER - TY - JOUR AU - Suzuki, H. AU - Tomida, A. AU - Tsuruo, T. PY - 2001 DA - 2001// TI - Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia JO - Oncogene VL - 20 UR - https://doi.org/10.1038/sj.onc.1204742 DO - 10.1038/sj.onc.1204742 ID - Suzuki2001 ER - TY - JOUR AU - Conrad, P. W. AU - Freeman, T. L. AU - Beitner-Johnson, D. AU - Millhorn, D. E. PY - 1999 DA - 1999// TI - EPAS1 trans-activation during hypoxia requires p42/p44 MAPK JO - J Biol Chem VL - 274 UR - https://doi.org/10.1074/jbc.274.47.33709 DO - 10.1074/jbc.274.47.33709 ID - Conrad1999 ER - TY - JOUR AU - Hashimoto, K. AU - Otero, M. AU - Imagawa, K. AU - de Andrés, M. C. AU - Coico, J. M. AU - Roach, H. I. AU - Oreffo, R. O. AU - Marcu, K. B. AU - Goldring, M. B. PY - 2013 DA - 2013// TI - Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1β) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M112.421156 DO - 10.1074/jbc.M112.421156 ID - Hashimoto2013 ER -