Table 3 Laboratory parameters before and after rosuvastatin treatment in SSc patients
Parameter | Pre-treatment mean (S.D.) | Post-treatment mean (S.D.) | P valuea |
|---|---|---|---|
Erythrocyte sedimentation rate (mm/hour) | 21 (15.6) | 24.7 (19) | ns (0.15) |
CRP (mg/L) | 5.1 (5.2) | 3.4 (2.7) | 0.01 |
Glucose (mmol/L) | 5.3 (1.0) | 5.5 (1.3) | ns (0.24) |
Urea (mmol/L) | 6.0 (2.4) | 5.9 (2.5) | ns (0.5) |
Creatinine (μmol/L) | 67.5 (19.7) | 63 (16.9) | ns (0.062) |
GFR (ml/min) | 82.1 (14.0) | 84.8 (10.8) | ns (0.078) |
Triglyceride (mmol/L) | 1.7 (0.97) | 1.3 (0.46) | 0.0004 |
Total cholesterol (mmol/L) | 5.3 (1.57) | 4.2 (1.28) | 0.0003 |
LDL (mmol/L) | 3.0 (1.3) | 2.2 (1.0) | 0.005 |
Non-HDL (mmol/L) | 3.8 (1.5) | 2.5 (1.3) | 0.0003 |
HDL (mmol/L) | 1.5 (0.84) | 1.5 (0.6) | ns (0.33) |
Uric acid (μmol/L) | 263 (56) | 273 (77) | ns (0.22) |
von Willebrand factor (%) | 209 (90) | 193 (75.6) | ns (0.092) |
Hemoglobin (g/L | 125 (12.7) | 126 (12.5) | ns (0.242) |
White blood cell count (109/L) | 6.7 (2.6) | 7.1 (2.7) | ns (0.191) |
Platelet count (109/L) | 250 (62) | 265 (64.5) | ns (0.064) |
Complement 3 (g/L) | 1.81 (0.4) | 1.62 (0.32) | 0.001 |
Complement 4 (g/L) | 0.31 (0.13) | 0.27 (0.1) | 0.001 |
Immune complex (extinction) | 183.6 (110) | 135.5 (55) | 0.005 |