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Table 1 Severity of symptoms and medications used during the month prior to assessment at baseline and 36 months

From: How do people with knee osteoarthritis use osteoarthritis pain medications and does this change over time? Data from the Osteoarthritis Initiative

Variable   Baseline
All patients
N = 987
Baseline
Followed up
N = 806
36 months
Followed up
N = 806
Pain NRS in most painful knee, mean ± SD   5.5 ± 2.4 5.4 ± 2.4 4.8 ± 2.8
Prescription analgesic used at any time   30.1% 29.4% 24.2%a
Prescription or OTC analgesic used frequentlyb   47.8% 47.9% 42.9%
Nutraceuticals used frequentlyb   41.3% 43.4% 36.0%a
Number of medications          Analgesics 0: 52.2% 52.1% 57.1%
used frequentlyb 1: 36.0% 37.6% 33.3%
  2: 9.9% 8.8% 7.8%
  ≥3: 1.9% 1.5% 1.8%
                                         Nutraceuticals 0: 58.7% 56.6% 64.0%a
  1: 4.1% 4.2% 4.1% a
  2: 30.1% 31.5% 22.8% a
  ≥3: 6.8% 7.7% 9.1% a
Patient-reported medication use:     
   Acetaminophenb   13.5% 12.5% 14.4%
   Prescription NSAIDsb   8.2% 8.1% 9.3%
   OTC NSAIDsb   26.8% 26.7% 21.3%a
   Coxibsb   10.2% 9.8% 4.7%a
   Opioidsb   3.3% 3.0% 5.0%
   Chondroitin and/or Glucosamineb   40.7% 42.9% 35.4%a
   Other nutraceuticalb   8.6% 8.8% 10.2%
   Intra-articular steroid injectionc   4.2% 4.3% 7.3%
   Intra-articular hyaluronan injectionc   2.0% 1.7% 3.3%
Medications brought into visit or identifiedd:   N = 820 N = 690 N = 690
   Proton pump inhibitor/H2 antagonist   11.2% 9.4% 21.4%
   NSAID   7.7% 6.6% 13.9%
   Coxib   11.6% 9.3% 5.2%
   NSAID + PPI (% of NSAID users)   7.2% (6/83) 9.4% (5/53) 26.0% (25/96)
   Coxib + PPI (% of coxib users)   34.9% (29/83) 30.7% (23/75) 41.7% (15/36)
  1. astatistically significant change from baseline; bfor more than ½ days in the previous month; cin the previous 6 months; din the previous month, brought in or identified in list of medication; Coxibs, COX-II inhibitors; KL, Kellgren-Lawrence; OTC, over the counter; NSAID, non-steroidal anti-inflammatory drug; NRS, numerical rating scale; PPI, proton pump inhibitor; SD, standard deviation.