Rheumatoid arthritis disease activity measured by Disease Activity Score in 28 joints score is decreased by pioglitazone. The graph on the left shows the change in Disease Activity Score in 28 joints high-sensitivity C-reactive protein (DAS28 CRP) scores among patients randomized to receive pioglitazone first, then placebo. The graph on the right shows change in DAS28-CRP scores among patients randomized to receive placebo first, then pioglitazone. Red designates patients taking pioglitazone, and black represents those taking placebo. Open circles represent mean change, and bars represent 95% confidence intervals.