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Table 3 Univariate analysis of baseline clinical and MSUS parameters

From: Predicting persistent inflammatory arthritis amongst early arthritis clinic patients in the UK: is musculoskeletal ultrasound required?

Clinical/Laboratory Parameters:

Overall cohort (n= 379)

Outcome diagnostic category

 
  

Non-PIA ( n = 217);

PIA ( n = 162);

P -value†

Age (years)

    

-cat; >50 (%)

51

49

51

0.533

-cont; mean (SD)

50.9 (36 to 66.)

48.5 (34.5 to 62.5)

53.8 (37.8 to 69.8)

0.057

Sex; F (%)

69

71

67

0.540

Ever smoked? (%)

54.1

100, 117

74, 88

0.999

Sx durn (weeks)

    

-cat; ≥20 (%)

51

61

38

<0.001

-cont; median (IQR)

20 (10 to 34)

24 (12 to 52)

12 (8 to 24)

<0.001

TJC /72

    

-cat; >6 (%)

51

48

54

0.299

-cont; median (IQR)

7 (2 to 14)

6 (2 to 14)

7.5 (3 to 15)

0.052

SJC /72

    

-cat; ≥1 (%)

46

26

73

<0.001

-cont; median (IQR)

0 (0 to 3)

0 (0 to 1)

2 (0 to 6)

<0.001

JPS

    

-cat; ≥2 (%)

66

56

78

<0.001

-cont; median (IQR)

2 (1.5 to 2)

2 (1.5 to 2)

2 (2 to 2.5)

<0.001

EMS (hours)

    

-cat; ≥1 (%)

50

39

65

<0.001

-cont; median (IQR)

1 (0.2 to 2)

0.5 (0.05 to 1.5)

1 (0.5 to 2)

<0.001

CRP (g/l)

    

-cat; <5,5 to 14,≥14 (%)

49,26,25

66, 23, 11

25, 30, 45

<0.001

-cont; median (IQR)

5 (<5 to 14)

<5 (<5 to 8)

11 (<5 to 32)

<0.001

ESR (mm/hr)

    

-cat; >24 (%)

50

33

72

<0.001

-cont; median (IQR)

24 (13 to 50)

18 (9 to 13)

45 (24 to 67)

<0.001

RF; Pos (%)

Neg, Pos

193, 24

97, 65

<0.001

ACPA; Pos (%)

Neg, Pos

216, 1

107, 55

<0.001

MSUS Parameters

Domain/Parameter

Definition

    

Grey-sale synovotis

∑ semi-quant. score/16 joints:

≥2 (%)

35.1

19.4

56.2

<0.001

 

∑ semi-quant score/6 joints (worst hand): ≥2 (%)

29.6

15

48.8

<0.001

 

Number of joints/16 scoring ≥1:

≥3 (%)

30.1

14.7

50.6

<0.001

Power Doppler synovitis

∑ semi-quant. Score/16 joints:

≥1 (%)

29

15.7

46.9

<0.001

 

Number of joints/16 scoring ≥1:

≥2 (%)

16.9

7.4

29.6

<0.001

  1. Baseline data for study cohort, and univariate analysis amongst patients with persistent inflammatory versus non-inflammatory diagnostic outcomes. Clinical and laboratory parameters are considered in both continuous (cont.) and categorical (cat.) formats. ACPA, anti-citrullinated peptide antibody; EMS, early morning stiffness; IQR, inter-quartile range; JPS, joint pattern score; RF, rheumatoid factor; SD, standard deviation, SxDur, symptom duration; T/SJC, tender/swollen joint count, (see Methods for derivation). Baseline MSUS data and corresponding univariate analysis (employing predetermined, optimal cut-off values for each dichotomous parameter) is also presented. ∑, sum of, semi-quant, semi-quantitative; PIA, persistent inflammatory arthritis. *Mann-Whitney U/Student's t tests for skewed/normally-distributed continuous data respectively; Pearson's χ2 with Yates' continuity correction for dichotomous data.
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Arthritis Research & Therapy

ISSN: 1478-6362

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