Skip to main content

Table 3 Univariate analysis of baseline clinical and MSUS parameters

From: Predicting persistent inflammatory arthritis amongst early arthritis clinic patients in the UK: is musculoskeletal ultrasound required?

Clinical/Laboratory Parameters: Overall cohort (n= 379) Outcome diagnostic category  
   Non-PIA ( n = 217); PIA ( n = 162); P -value†
Age (years)     
-cat; >50 (%) 51 49 51 0.533
-cont; mean (SD) 50.9 (36 to 66.) 48.5 (34.5 to 62.5) 53.8 (37.8 to 69.8) 0.057
Sex; F (%) 69 71 67 0.540
Ever smoked? (%) 54.1 100, 117 74, 88 0.999
Sx durn (weeks)     
-cat; ≥20 (%) 51 61 38 <0.001
-cont; median (IQR) 20 (10 to 34) 24 (12 to 52) 12 (8 to 24) <0.001
TJC /72     
-cat; >6 (%) 51 48 54 0.299
-cont; median (IQR) 7 (2 to 14) 6 (2 to 14) 7.5 (3 to 15) 0.052
SJC /72     
-cat; ≥1 (%) 46 26 73 <0.001
-cont; median (IQR) 0 (0 to 3) 0 (0 to 1) 2 (0 to 6) <0.001
JPS     
-cat; ≥2 (%) 66 56 78 <0.001
-cont; median (IQR) 2 (1.5 to 2) 2 (1.5 to 2) 2 (2 to 2.5) <0.001
EMS (hours)     
-cat; ≥1 (%) 50 39 65 <0.001
-cont; median (IQR) 1 (0.2 to 2) 0.5 (0.05 to 1.5) 1 (0.5 to 2) <0.001
CRP (g/l)     
-cat; <5,5 to 14,≥14 (%) 49,26,25 66, 23, 11 25, 30, 45 <0.001
-cont; median (IQR) 5 (<5 to 14) <5 (<5 to 8) 11 (<5 to 32) <0.001
ESR (mm/hr)     
-cat; >24 (%) 50 33 72 <0.001
-cont; median (IQR) 24 (13 to 50) 18 (9 to 13) 45 (24 to 67) <0.001
RF; Pos (%) Neg, Pos 193, 24 97, 65 <0.001
ACPA; Pos (%) Neg, Pos 216, 1 107, 55 <0.001
MSUS Parameters
Domain/Parameter
Definition
    
Grey-sale synovotis ∑ semi-quant. score/16 joints:
≥2 (%)
35.1 19.4 56.2 <0.001
  ∑ semi-quant score/6 joints (worst hand): ≥2 (%) 29.6 15 48.8 <0.001
  Number of joints/16 scoring ≥1:
≥3 (%)
30.1 14.7 50.6 <0.001
Power Doppler synovitis ∑ semi-quant. Score/16 joints:
≥1 (%)
29 15.7 46.9 <0.001
  Number of joints/16 scoring ≥1:
≥2 (%)
16.9 7.4 29.6 <0.001
  1. Baseline data for study cohort, and univariate analysis amongst patients with persistent inflammatory versus non-inflammatory diagnostic outcomes. Clinical and laboratory parameters are considered in both continuous (cont.) and categorical (cat.) formats. ACPA, anti-citrullinated peptide antibody; EMS, early morning stiffness; IQR, inter-quartile range; JPS, joint pattern score; RF, rheumatoid factor; SD, standard deviation, SxDur, symptom duration; T/SJC, tender/swollen joint count, (see Methods for derivation). Baseline MSUS data and corresponding univariate analysis (employing predetermined, optimal cut-off values for each dichotomous parameter) is also presented. ∑, sum of, semi-quant, semi-quantitative; PIA, persistent inflammatory arthritis. *Mann-Whitney U/Student's t tests for skewed/normally-distributed continuous data respectively; Pearson's χ2 with Yates' continuity correction for dichotomous data.