Synovitis, bone erosion, and cartilage degradation histology scores in young Tg197 mice. Joint tissues were harvested at baseline (n = 5) and after 6 weeks of saline treatment (n = 10) or 6 weeks (n = 5) or 16 weeks (n = 5) of treatment with anti-TNF-α monoclonal antibodies. All paws were subjected to blinded histologic analysis. *P < 0.05, versus baseline. mAb, monoclonal antibody; TNF, tumor necrosis factor.