Anti-TNF-α treatment reverses weight loss in arthritic animals. (a) Young (at 7 to 8 weeks of age) or (b) aged mice (at 27 to 28 weeks of age) with established arthritis (arthritic score of 2 in at least two limbs) were randomized to three groups to be humanely killed immediately (baseline, n = 5) or to receive weekly doses of saline (open circle, n = 10) or 10 mg/kg of anti-TNF-α (closed square, n = 10 through 6 weeks and n = 5 from 7 to 16 weeks). Weight gain was measured as change from pretreatment weight. *P < 0.05, versus saline controls, and remained significant until the end of the study. TNF, tumor necrosis factor.