TY - JOUR AU - Purmessur, Devina AU - Guterl, Clare C. AU - Cho, Samuel K. AU - Cornejo, Marisa C. AU - Lam, Ying W. AU - Ballif, Bryan A. AU - Laudier, Damien M. AU - Iatridis, James C. PY - 2013 DA - 2013/09/17 TI - Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development JO - Arthritis Research & Therapy SP - R122 VL - 15 IS - 5 AB - Notochordal cells (NCs) pattern aneural and avascular intervertebral discs (IVDs), and their disappearance, is associated with onset of IVD degeneration. This study induced and characterized the maturation of nucleus pulposus (NP) tissue from a gelatinous NC-rich structure to a matrix-rich structure populated by small NP cells using dynamic pressurization in an ex vivo culture model, and also identified soluble factors from NCs with therapeutic potential. SN - 1478-6354 UR - https://doi.org/10.1186/ar4302 DO - 10.1186/ar4302 ID - Purmessur2013 ER -