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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development

Figure 5

Safranin O/Fast green staining of Control, 1 Dose and Daily pressurized nucleus pulposus tissue. (A) Nucleus pulposus (NP) tissue demonstrated increased accumulation of proteoglycan (red staining) with pressurization and this was greatest with the Daily pressurization group. (B) A notable change in cell morphology was also observed with loading, with fewer large notochordal cells (NCs) and increased numbers of small nucleus pulposus cell (SNPCs) with load compared with the Control group (black bars). The 1 Dose pressurization group also demonstrated significant differences from the Control group (grey bars) and there were significant differences between NCs and SNPCs in the Control and Daily pressurization groups (*). To quantify this, the number of large NCs versus SNPCs was calculated based on the criteria shown in Figure 2 (P < 0.0002).

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Arthritis Research & Therapy

ISSN: 1478-6362

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