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Table 3 Mean fluorescence ratios (standardized for overall perfusion of the hand) for joints with compared with those without evidence of synovitis determined by clinical examination or established imaging techniques #

From: Quantitative assessment of synovitis in patients with rheumatoid arthritis using fluorescence optical imaging

  

Ratio FOI phase 1 (1 – 120 seconds)

Ratio FOI phase 2 (121 – 240 seconds)

Ratio FOI phase 3 (241 – 360 seconds)

Synovitis

n

Mean ± SD

P

Mean ± SD

P

Mean ± SD

P

TJ yes

44

1.02 ± 0.45

ns

1.31 ± 0.48

*

1.33 ± 0.48

*

TJ no

46

0.93 ± 0.33

1.10 ± 0.23

1.13 ± 0.24

SJ yes

26

1.13 ± 0.50

*

1.43 ± 0.54

**

1.45 ± 0.54

**

SJ no

64

0.91 ± 0.33

1.11 ± 0.26

1.14 ± 0.26

GSUS yes

39

1.06 ± 0.47

ns

1.33 ± 0.48

*

1.37 ± 0.48

**

GSUS no

51

0.91 ± 0.32

1.10 ± 0.26

1.12 ± 0.26

CDUS yes

23

1.22 ± 0.46

**

1.52 ± 0.52

**

1.53 ± 0.53

**

CDUS no

67

0.89 ± 0.33

1.09 ± 0.26

1.12 ± 0.26

MRI yes

39§

1.11 ± 0.46

**

1.38 ± 0.47

***

1.41 ± 0.46

***

MRI no

40§

0.86 ± 0.33

1.06 ± 0.26

1.08 ± 0.26

All

90

0.97 ± 0.39

 

1.20 ± 0.39

 

1.22 ± 0.39

 
  1. # Fluorescence ratios were derived by dividing the readout of each joint by the readout of the control area of the eponychium of the index finger; § 11 joints could not be evaluated with MRI; *P<0.05; **P<0.01; ***P<0.001.
  2. CDUS, color Doppler ultrasonography; FOI, fluorescence optical imaging; GSUS, grey-scale ultrasonography; MRI, magnetic resonance imaging; ns, comparison was not significant (P≥0.05 with student’s t-test); SD, standard deviation; SJ, swollen joint by clinical examination; TJ, tender joint by clinical examination.