Prophylactic administration of sclerostin antibody to CIA mice does not prevent focal bone erosion in periarticular bone in the knee joint. (A, B) Bar plots represent mean (and standard deviation of) ratio between bone surface and bone volume (BS/BV), representing surface density, and ankle joint bone volume (BV), respectively. (C) Representative three-dimensional renditions of the knee joint scanned by micro computed tomography. The one-way ANOVA test with Tukey's post hoc comparison was used for statistical evaluation of all parameters shown in the bar plots. #P < 0.05 for the difference versus collagen-induced arthritis (CIA) + PBS.