Illustration of a hypothetical patient showing the target tophus responses and overall tophus response. The diagram shows the tophus scoring system for a sample patient with four baseline tophi (three measurable and one unmeasurable). Tophus area was defined for each measurable tophus using the longest dimension and its perpendicular axis. The circle marks the unmeasurable tophus. Each baseline target tophus was rescored at all subsequent study visits. The patient illustrated in the figure had a best “overall” response of complete response (CR) because the patient had at least one target tophus response of CR and no new or progressing tophi at any time during the study. PR, partial response; SD, stable disease.