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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Murine analogues of etanercept and of F8-IL10 inhibit the progression of collagen-induced arthritis in the mouse

Figure 6

Analysis of cytokine levels in mice with full collagen-induced arthritis. At the end of the therapy 13 different cytokine concentrations were measured in plasma using multiplex bead-based flow cytometry. Data points of cytokine concentrations above detection level are represented in a scatter plot with the mean ± standard error of the mean (n = 7). Standard curves defined with positive control samples (Additional file 5) were used to generate a level of quantification (LOQ; dotted red line). Most of the measured concentrations were below the LOQ, but a significant increase in the level of IL-27 was observed for F8-huIL10 and the combination versus saline (*P = 0.0017 and P = 0.038, respectively). IFN, interferon; IL, interleukin; TNF, tumor necrosis factor.

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