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Table 1 Role of IFN-γ in various models of autoimmunity.

From: Paradoxical roles of IFN-γ in models of Th1-mediated autoimmunity

Autoimmune model Immunopathogenic mechanism Genetic deletion Effect on disease incidence or severity References
Experimental autoimmune encephalomyelitis T cells IFN-γ Increased [10]
Experimental autoimmune myasthenia gravis Antibody IFN-γR Decreased [10]
Experimental autoimmune thyroiditis T cells IFN-γR Accelerated, less severe [5]
Collagen-induced arthritis Antibody IFN-γR & IFN-γ Increased [68]
Uveitis T cells IFN-γ Increased [4]
Proteoglycan-induced arthritis T cells IFN-γ Decreased [11]