Paradoxical roles of IFN-γ in models of Th1-mediated autoimmunity

Table 1 Role of IFN-γ in various models of autoimmunity.

Autoimmune model	Immunopathogenic mechanism	Genetic deletion	Effect on disease incidence or severity	References
Experimental autoimmune encephalomyelitis	T cells	IFN-γ	Increased	[10]
Experimental autoimmune myasthenia gravis	Antibody	IFN-γR	Decreased	[10]
Experimental autoimmune thyroiditis	T cells	IFN-γR	Accelerated, less severe	[5]
Collagen-induced arthritis	Antibody	IFN-γR & IFN-γ	Increased	[6–8]
Uveitis	T cells	IFN-γ	Increased	[4]
Proteoglycan-induced arthritis	T cells	IFN-γ	Decreased	[11]

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