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Table 1 Peptide sets immobilized on the microarrays for surface plasmon resonance imaging analysis a

From: ACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline or with disease progression

Set   Origin Peptide sequence Position of citrulline residuesb
1 A α-enolase (cyclic) CKIHAR EIFDSR GNPTVECZO  
  B   CKIHAX EIFDSX GNPTVECZO 9, 15
2 A β-actin MKILTER GYSFTTAER EIVRDIKEKLZO  
  B   MKILTEX GYSFTTAEX EIVXDIKEKLZO 196, 206, 210
3 A CCP2-like (cyclic) c  
  B    n.r.
4 A Collagen type II GLPGVKGHR GYPGLDGAZO  
  B   GLPGVKGHX GYPGLDGAZO 290
5 A Fibrinogen FLAEGGGVR GPRVVERHZO  
  B   FLAEGGGVX GPRVVERHZO α35d
6 A Fibrinogen TSSTSYNR GDSTFZO  
  B   TSSTSYNX GDSTFZO α591d
7 A Fibrinogen NEEGFFSAR GHRPLDKKZO  
  B   NEEGFFSAX GHRPLDKKZO β44e
8 A Fibrinogen EEAPSLR PAPPPISGGGYR AR PAKAAAZO  
  B   EEAPSLX PAPPPISGGGYX AX PAKAAAZO β60, 72, 74e
9 A Fibronectin LTVGLTRR GQPRQYZO  
  B   LTVGLTXX GQPRQYZO 1,035, 1,036
10 A Fibronectin YNQYSQR YHQRTNZO  
  B   YNQYSQX YHQRTNZO 2356
11 A Filaggrin (cfc1; cyclic) HQCESTR GRSRGRCGRSGSZO f
  B   HQCESTX GRSRGRCGRSGSZO  
12 A MNDA KLTSEAR GR IPVAQKZO  
  B   KLTSEAX GX IPVAQKZO 127, 129
13 A Peptide library c  
  B    n.r.
14 A Peptide library c  
  B    n.r.
15 A Peptide library c  
  B    n.r.
16 A Peptide library c  
  B    n.r.
17 A Vimentin MSTR SVSSSSYRR MFGGPZO  
  B   MSTX SVSSSSYXX MFGGPZO 4, 12, 13
18 A Vimentin GVYATR SSAVR LR SSVPGZO  
  B   GVYATX SSAVX LX SSVPGZO 64, 69, 71
19 A Vimentin LTAALR DVR QQYESZO  
  B   LTAALX DVX QQYESZO 270, 273
20 A Vimentin SLNLR ETNLDSLPLVDZO  
  B   SLNLX ETNLDSLPLVDZO 424
  1. aCCP2, cyclic citrullinated peptide 2; MNDA, myeloid cell nuclear differentiation antigen; n.r., not relevant; O, biotinylated lysine; X, citrulline; Z, aminohexanoic acid. bAmino acid position in the corresponding polypeptide relative to the N-terminal methionine of the primary translation product. cSequence is defined in patent EP2071335. dα-Chain of fibrinogen. eβ-Chain of fibrinogen. fDerived from sequence presented in [27].