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Table 1 Allelic frequencies of the HLA-A and HLA-B allele groups in Behçet’s disease patients and healthy controls a

From: HLA and non-HLA genes in Behçet’s disease: a multicentric study in the Spanish population

Region BD patients Controls P OR (95% CI)
HLA-A 2n = 542 (%) 2n = 626 (%)   
01 51 (0.09) 63 (0.10)   
02 186 (0.34) 164 (0.26) 0.003 1.47 (1.14 to 1.91)
03 34 (0.06) 70 (0.11) 0.003 0.53 (0.34 to 0.83)
11 31 (0.06) 47 (0.08)   
23 20 (0.04) 25 (0.04)   
24 59 (0.11) 42 (0.07) 0.01 1.70 (1.10 to 2.62)
25 3 (0.005) 8 (0.01)   
26 19 (0.03) 27 (0.04)   
29 40 (0.07) 50 (0.08)   
30 23 (0.04) 33 (0.05)   
31 19 (0.03) 13 (0.02)   
32 18 (0.03) 22 (0.03)   
33 11 (0.02) 20 (0.03)   
34 2 (0.004) 0 (0.0)   
36 1 (0.002) 0 (0.0)   
66 7 (0.01) 5 (0.008)   
68 16 (0.03) 32 (0.05)   
69 1 (0.002) 4 (0.006)   
80 1 (0.002) 1 (0.002)   
HLA-B 2n = 548 (%) 2n = 626 (%)   
07 34 (0.06) 40 (0.06)   
08 25 (0.05) 25 (0.04)   
13 5 (0.009) 5 (0.008)   
14 35 (0.06) 57 (0.09)   
15 35 (0.06) 24 (0.04)   
18 29 (0.05) 55 (0.09) 0.02 0.58 (0.35 to 0.95)
27 16 (0.03) 19 (0.03)   
35 36 (0.07) 78 (0.12) 0.0007 0.49 (0.32 to 0.76)
37 3 (0.005) 3 (0.004)   
38 12 (0.02) 28 (0.04) 0.03 0.48 (0.23 to 0.99)
39 5 (0.009) 10 (0.02)   
40 14 (0.02) 22 (0.03)   
41 5 (0.009) 7 (0.01)   
42 1 (0.002) 0 (0.0)   
44 70 (0.13) 88 (0.14)   
45 8 (0.01) 16 (0.03)   
46 1 (0.002) 0 (0.0)   
47 1 (0.002) 1 (0.002)   
48 0 (0.0) 2 (0.003)   
49 17 (0.03) 35 (0.06)   
50 13 (0.02) 20 (0.03)   
51 125 (0.23) 42 (0.07) <10–7 4.11 (2.79 to 6.06)
52 5 (0.009) 8 (0.01)   
53 8 (0.01) 14 (0.02)   
54 0 (0.0) 1 (0.002)   
55 6 (0.01) 3 (0.005)   
56 4 (0.007) 1 (0.002)   
57 34 (0.06) 11 (0.02) 0.00008 3.70 (1.78 to 7.83)
58 1 (0.002) 11 (0.02) 0.007 0.10 ( 0.0 to 0.71)
  1. aBD, Behçet’s disease; CI, confidence interval; OR, odds ratio; HLA, human leukocyte antigen. An allelic model was used. Allelic frequencies, calculated as the number of each specific allele divided by the total number of alleles (number of individuals × 2 (2n)), are shown within parentheses. Only those P-values ≤0.05 are indicated. P-values ≤0.001 were considered statistically significant, and the corresponding HLAs were considered to be associated. HLAs with P-values between 0.001 and 0.01 were considered suggestive of association, and those with P-values between 0.01 and 0.05 were considered marginally associated. The rest of the HLA specificities described (A*43, A*74, B*59, B67, B*73, B*78, B*81 and B*83) were not detected in our population.