Table 2 Esophageal complications and interstitial lung disease characteristics of anti-Jo1-positive antisynthetase syndrome patients a
From: Functional outcome and prognostic factors in anti-Jo1 patients with antisynthetase syndrome
Complications and characteristics | Percentage ( n) |
|---|---|
Esophageal complications (N = 21) | |
 Time of onset | |
 Concomitant with PM/DM | 19% (n = 4) |
 1 to 3 months after PM/DM diagnosis | 28.6% (n = 6) |
 More than 3 months after PM/DM diagnosis | 52.4% (n = 11) |
 Presenting symptoms |  |
  Odynophagia | 4.8% (n = 1) |
  Dysphagia | 81% (n = 17) |
  GER into pharynx and/or mouth | 33.3% (n = 7) |
  Coughing while eating | 61.9% (n = 13) |
  Aphagia for solids and liquids | 14.3% (n = 3) |
 Esophageal manometry |  |
  Low pressure in upper esophageal sphincter | 85.7% (n = 18) |
  Decreased peristalsis in upper third of esophageal body | 85.7% (n = 18) |
  Absent peristalsis in upper third of esophageal body | 14.3% (n = 3) |
  Decreased peristalsis in lower two-thirds of esophageal body | 9.5% (n = 2) |
Interstitial lung disease (N = 55) |  |
 Time of onset |  |
  Before PM/DM | 10.9% (n = 6) |
  Concomitant with PM/DM | 70.9% (n = 39) |
  After PM/DM | 18.2% (n = 10) |
 PFT |  |
  FVC (median) | 74% |
  VC (median) | 75% |
  DLCO (median) | 61% |
 HRCT scan pattern |  |
  COP | 12.7% (n = 7) |
  NSIP | 63.7% (n = 35) |
  UIP | 23.6% (n = 13) |