Table 2 Esophageal complications and interstitial lung disease characteristics of anti-Jo1-positive antisynthetase syndrome patients a
From: Functional outcome and prognostic factors in anti-Jo1 patients with antisynthetase syndrome
| Complications and characteristics | Percentage ( n) |
|---|---|
| Esophageal complications (N = 21) | |
| Time of onset | |
| Concomitant with PM/DM | 19% (n = 4) |
| 1 to 3 months after PM/DM diagnosis | 28.6% (n = 6) |
| More than 3 months after PM/DM diagnosis | 52.4% (n = 11) |
| Presenting symptoms | |
| Odynophagia | 4.8% (n = 1) |
| Dysphagia | 81% (n = 17) |
| GER into pharynx and/or mouth | 33.3% (n = 7) |
| Coughing while eating | 61.9% (n = 13) |
| Aphagia for solids and liquids | 14.3% (n = 3) |
| Esophageal manometry | |
| Low pressure in upper esophageal sphincter | 85.7% (n = 18) |
| Decreased peristalsis in upper third of esophageal body | 85.7% (n = 18) |
| Absent peristalsis in upper third of esophageal body | 14.3% (n = 3) |
| Decreased peristalsis in lower two-thirds of esophageal body | 9.5% (n = 2) |
| Interstitial lung disease (N = 55) | |
| Time of onset | |
| Before PM/DM | 10.9% (n = 6) |
| Concomitant with PM/DM | 70.9% (n = 39) |
| After PM/DM | 18.2% (n = 10) |
| PFT | |
| FVC (median) | 74% |
| VC (median) | 75% |
| DLCO (median) | 61% |
| HRCT scan pattern | |
| COP | 12.7% (n = 7) |
| NSIP | 63.7% (n = 35) |
| UIP | 23.6% (n = 13) |