From: Functional outcome and prognostic factors in anti-Jo1 patients with antisynthetase syndrome
Complications and characteristics | Percentage ( n) |
---|---|
Esophageal complications (N = 21) | |
Time of onset | |
Concomitant with PM/DM | 19% (n = 4) |
1 to 3 months after PM/DM diagnosis | 28.6% (n = 6) |
More than 3 months after PM/DM diagnosis | 52.4% (n = 11) |
Presenting symptoms | |
Odynophagia | 4.8% (n = 1) |
Dysphagia | 81% (n = 17) |
GER into pharynx and/or mouth | 33.3% (n = 7) |
Coughing while eating | 61.9% (n = 13) |
Aphagia for solids and liquids | 14.3% (n = 3) |
Esophageal manometry | |
Low pressure in upper esophageal sphincter | 85.7% (n = 18) |
Decreased peristalsis in upper third of esophageal body | 85.7% (n = 18) |
Absent peristalsis in upper third of esophageal body | 14.3% (n = 3) |
Decreased peristalsis in lower two-thirds of esophageal body | 9.5% (n = 2) |
Interstitial lung disease (N = 55) | |
Time of onset | |
Before PM/DM | 10.9% (n = 6) |
Concomitant with PM/DM | 70.9% (n = 39) |
After PM/DM | 18.2% (n = 10) |
PFT | |
FVC (median) | 74% |
VC (median) | 75% |
DLCO (median) | 61% |
HRCT scan pattern | |
COP | 12.7% (n = 7) |
NSIP | 63.7% (n = 35) |
UIP | 23.6% (n = 13) |