Figure 2From: Th17 cells favor inflammatory responses while inhibiting type I collagen deposition by dermal fibroblasts: differential effects in healthy and systemic sclerosis fibroblastsIL-17A enhances MCP-1, IL-8 and MMP-1 but not collagen production in HD and SSc fibroblasts. Dermal fibroblasts were cultured in the presence of 30Â ng/ml of IL-17A. Protein levels are expressed as fold change relative to control condition (medium with no IL-17A, dotted line) assessed in 48-hour culture supernatants by ELISA (MCP-1, IL-8, MMP-1) and RIA (collagen). Each symbol represents a distinct individual and the horizontal lines depict the median. Significant differences relative to the control condition were assessed by the Wilcoxon signed-rank test.ELISA: enzyme-linked immunosorbent assay; IL: interleukin; MCP-1: monocyte chemotactic protein-1; MMP-1: matrix metalloprotein-1; RIA : radio-immune assay.Back to article page