Table 2 Cytokines assessed in supernatants of cultured CD1c + myeloid dendritic cells derived from PB and SF of rheumatoid arthritis patients
| Â | PB (pg/ml) | SF (pg/ml) |
|---|---|---|
Proinflammatory cytokines | Â | Â |
IL-1α | 409 (150) | 344 (343) |
IL-1β | 258 (65.5) | 298 (280) |
IL-1RA | 2,561 (1,034) | 2,769 (3,531) |
IL-6 | 41.0 (13.3) | 29.6 (22.6) |
IL-6R | 324 (100) | 343 (199) |
IL-18 | 149 (47.9) | 180 (165) |
Tumour necrosis factor alpha | 99.1 (95.5) | 170 (165) |
Interferon alpha | 153 (69.5) | 157 (168) |
Thymic stromal lymphopoeitin | <LDL | <LDL |
T cell-differentiating and T cell-activating cytokines | ||
IL-12p70 | 17.6 (11.1) | 18.9 (18.5) |
IL-23 | 444 (354) | 420 (393) |
IL-33 | 260 (101) | 336 (391) |
IL-13 | 857 (387) | 1,054 (1,426) |
IL-10 | 112 (49.9) | 126 (63.1) |
Macrophage migration inhibitory factor | 1,872 (704) | 2,948 (1,960) |
IL-7 | 25.8 (6.9) | 29.2 (29.7) |
IL-9 | 3,087 (1,195) | 3,280 (3,758) |
IL-15 | 21.7 (8.7) | 29.4 (27.3) |
IL-21 | 5,114 (1,834) | 6,343 (4,710) |
IL-22 | 19.2 (6.1) | 29.0 (27.3) |
IL-25 | 1,140 (526) | 1,239 (1,310) |
Chemokines | ||
IL-16 | 239 (101) | 633 (581)†|
CCL2/MCP1 | 29.7 (18.5) | 24.6 (25.5) |
CCL3/MIP1α | 1,268 (1,847) | 2,776 (3,954) |
CCL5/RANTES | <LDL | <LDL |
CCL17/TARC | 1.2 (0.5) | 26.4 (23.6)** |
CCL19/MIP3β | 28.4 (11.5) | 57.5 (51.5) |
CCL22/MDC | 4,397 (1,627) | 2,456 (1,023)* |
CXCL9/MIG | 23.9 (16.1) | 90.4 (67.9)** |
CXCL10/IP-10 | 54.0 (70.3) | 247 (310)* |
Growth factors/others | ||
Oncostatin M | 28.0 (21.7) | 23.5 (17.8) |
Fibroblast growth factor basic | 4,046 (1,647) | 4,777 (5,559) |
Nerve growth factor | 63.0 (23.2) | 76.7 (90.2) |
Hepatocyte growth factor | 118 (46.8) | 151 (143) |
Granulocyte–macrophage colony-stimulating factor | 650 (283) | 827 (859) |
Macrophage colony-stimulating factor | 484 (188) | 571 (730) |
Vascular endothelial growth factor | 191 (110) | 202 (125) |
IL-11 | 49.6 (20.1) | 53.6 (63.9) |
Soluble intracellular adhesion molecule-1 | 34,067 (139,11) | 37,260 (46,225) |
Osteopontin | 11,192 (4,471) | 15,528 (10,471) |
Matrix metalloproteinase-8 | 2,237 (1,594) | 2,742 (4,634) |
Tissue inhibitor of metalloproteinases-1 | 2,689 (1,126) | 2,455 (2,169) |
Cathepsin B | 4,204 (1,554) | 6,283 (4,948) |
Cathepsin L | 215 (101) | 594 (731) |
Cathepsin S | 133 (55.3) | 159 (130) |