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Table 2 Concordance between HLA-B27 and tagging SNP rs4349859 and rs116488202 genotypes in New Zealand controls and ankylosing spondylitis patients

From: Prevalence of HLA-B27 in the New Zealand population: effect of age and ethnicity

Phenotype

Frequency (n(%))

Genotype concordance (%)

HLA-B27-positiveα

rs4349859-positiveb

rs116488202-positive

rs4349859

rs116488202

Controls

Caucasian

9/117 (7.7)

9/117 (7.7)

9/117 (7.7)

100.0

100.0

 

New Zealand Māori

7/107 (6.5)

6/107 (5.6)

6/107 (5.6)

85.7

85.7

AS

Overall

164/176 (93.2)

159/176 (90.3)

159/176 (90.3)

96.9

97.6

 

Caucasian

151/162 (93.2)

149/162 (91.9)c

150/162 (92.6)d

98.7

99.3

 

New Zealand Māori

13/14 (92.9)

10/14 (71.4)

10/14 (71.4)

76.9

76.9

  1. AS, ankylosing spondylitis; SNP, single nucleotide polymorphism.
  2. αHLA-B27 status determined by human leucocyte antigen (HLA) typing.
  3. bStudy participants were positive if heterozygous or homozygous for the minor allele of rs4349859 or rs116488202.
  4. cOne patient was HLA-B*2705-positive by typing but was negative for the minor allele of both tagging SNPs.
  5. dOne patient was HLA-B*2705-positive by typing but was negative for the minor allele of rs4349859.
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Arthritis Research & Therapy

ISSN: 1478-6362

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