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Table 2 Concordance between HLA-B27 and tagging SNP rs4349859 and rs116488202 genotypes in New Zealand controls and ankylosing spondylitis patients

From: Prevalence of HLA-B27 in the New Zealand population: effect of age and ethnicity

Phenotype Frequency (n(%)) Genotype concordance (%)
HLA-B27-positiveα rs4349859-positiveb rs116488202-positive rs4349859 rs116488202
Controls Caucasian 9/117 (7.7) 9/117 (7.7) 9/117 (7.7) 100.0 100.0
  New Zealand Māori 7/107 (6.5) 6/107 (5.6) 6/107 (5.6) 85.7 85.7
AS Overall 164/176 (93.2) 159/176 (90.3) 159/176 (90.3) 96.9 97.6
  Caucasian 151/162 (93.2) 149/162 (91.9)c 150/162 (92.6)d 98.7 99.3
  New Zealand Māori 13/14 (92.9) 10/14 (71.4) 10/14 (71.4) 76.9 76.9
  1. AS, ankylosing spondylitis; SNP, single nucleotide polymorphism.
  2. αHLA-B27 status determined by human leucocyte antigen (HLA) typing.
  3. bStudy participants were positive if heterozygous or homozygous for the minor allele of rs4349859 or rs116488202.
  4. cOne patient was HLA-B*2705-positive by typing but was negative for the minor allele of both tagging SNPs.
  5. dOne patient was HLA-B*2705-positive by typing but was negative for the minor allele of rs4349859.