Immunomodulating properties of DPTTS in mice with HOCl-induced SSc. (a) Splenic B-cell numbers (B220 epitope), as assessed with flow cytometry. (b) Proliferation of splenic T cells activated by anti-CD3/CD28. (c) Proliferation of splenic B cells activated by LPS. Results are expressed in cpm. (d, e) Concentrations of IL-4 and IL-13 in supernatants of ConA-activated splenic T cells. Values are expressed as mean ± SEM of data gained from all mice in the experimental and control groups. *P < 0.05; **P < 0.01; ***P < 0.001.