Extent of significant alterations during emergence and onset of overt Sjögren’s syndrome. (A) Number of exclusive GSs (GSs yielding significance in C57BL/6.NOD-Aec1Aec2 mice only), reciprocal GSs (GSs yielding significance in C57BL/6.NOD-Aec1Aec2 and C57BL/6 mice, but with opposite trends) and parallel GSs (GSs yielding significance in C57BL/6.NOD-Aec1Aec2 mice and C57BL/6 mice with the same trend (excluded)). (B) Number of extracellular milieu(EM)-related and EM-associated gene sets (GSs) significantly altered for each time period. (C) Number of leading edge (LE) genes underlying the changes displayed in (A), categorized with respect to localization inside or outside the susceptibility regions Aec1 and Aec2. (D) Number of LE genes underlying each of the major biological themes.