Annotation of the Markov cluster algorithm clusters with their respective leading edge gene clouds. The individual gene sets (GSs) of each Markov cluster algorithm cluster shown in Figure 3 were collapsed into a metanode. Network: metanode color represents the original color of the ancestor GSs and node size and node label font size are proportional to the number of GSs collapsed into this metanode (reference node = 15 GSs). Clustered leading edge (LE) gene clouds: Font color represents clustering of the LE genes based on the connections between the original GSs. Font size is proportional to the frequency of the gene in the LEs of the GSs collapsed into this metanode.