Enrichments in the transcriptional landscape of the extracellular milieu during transition from subclinical to overt Sjögren’s syndrome. (A) Gene sets (GSs) enriched at 16 weeks of age mirror the establishment of a pathogenic immune reaction in the targeted tissues and, in addition, reflect partial normalization of prior neurotransmitter receptor gene-associated alterations. The layout parameters correspond precisely to the layout parameters of Figure 3. The reference node allows estimation of scaling and direct comparison of Figures 3, 5A, 6A and 7A and Additional file 1: Figure S2A. ACh, acetylcholine; GABA, γ-aminobutyric acid; Gly, glycine; MHCII, major histocompatibility complex class II; NK, natural killer. (B) Annotation of the Markov cluster algorithm clusters displayed in Figure 5A with their respective leading edge gene clouds. The layout parameters of Figure 5B correspond precisely to the layout parameters of Figure 4. The reference node allows estimation of scaling and direct comparison of Figures 4, 5B, 6B and 7B and Additional file 1: Figure S2B.