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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis

Figure 1

A cholesterol-rich diet leads to increased serum LDL levels and ApoB accumulation in synovial lining. Both WT and LDLr deficient mice received a normal or cholesterol-rich diet for 120 days. Increased body weight following a cholesterol-rich diet was observed in WT mice but not in LDLr deficient mice (A). Serum LDL levels were increased both in WT and LDLr deficient animals after receiving a cholesterol-rich diet (B). Synovial lining cells (predominantly macrophages) of LDLr deficient mice showed increased intracellular ApoB accumulation, suggesting increased oxLDL uptake (C). *P<0.05; ***P<0.001 versus WT mice with normal diet; ‡P<0.001 versus LDLr deficient mice with normal diet and WT mice with cholesterol-rich diet. n = 10 mice per group. ApoB, apolipoprotein B; LDL, low density lipoprotein; LDLr, low density lipoprotein receptor; oxLDL, oxidized low density lipoprotein; WT, wild type.

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