Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes

Klingberg, Eva; Lorentzon, Mattias; Göthlin, Jan; Mellström, Dan; Geijer, Mats; Ohlsson, Claes; Atkinson, Elizabeth J; Khosla, Sundeep; Carlsten, Hans; Forsblad-d’Elia, Helena

doi:10.1186/ar4368

Table 3 The correlation (Spearman rho) between the HRpQCT parameters, age, lumbar QCT, and mSASSS in the AS patients

From: Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes

HRpQCT radius	DTrab (mg/cm³)	BV/TV (%)	Tbth (μm)	TbN (per mm)	TbSp (μm)	DCort (mg/cm³)	CortTh (μm)	CtPo (%)	CtPoDiam (μm)
Age	-0.471	-0.473	-0.507	-0.040	0.166	-0.337	-0.228	0.540	0.055
Age	P < 0.001	P < 0.001	P < 0.001	P = 0.755	P = 0.198	P = 0.007	P = 0.075	P < 0.001	P = 0.663
Lumb QCT	0.762	0.763	0.737	0.106	-0.304	0.425	0.420	-0.480	- 0.136
Trab vBMD	P < 0.001	P < 0.001	P < 0.001	P = 421	P = 0.018	P = 0.001	P = 0.001	P < 0.001	P = 0.290
Lumb QCT	0.296	0.298	0.152	0.296	- 0.341	0.123	0.152	0.032	0.006
Cort vBMD	P = 0.021	P = 0.021	P = 0.246	P = 0.022	P = 0.008	P = 0.348	P = 247	P = 0.805	P = 0.961
Msasss	- 0.400	- 0.400	- 0.528	0.077	0.039	- 0.192	- 0.196	0.352	0.022
Msasss	P = 0.001	P = 0.001	P < 0.001	P = 0.552	P = 0.761	P = 0.135	P = 0.128	P = 0.004	P = 0.861
HRpQCT tibia	DTrab	BV/TV	Tbth	TbN	TbSp	DCort	CortTh	CtPo	CtPoDiam
HRpQCT tibia	(mg/cm³)	(%)	(μm)	(mm^-1)	(μm)	(mg/cm³)	(μm)	(%)	(μm)
Age	- 0.470	- 0.471	- 0.479	- 0.185	0.246	- 0.436	- 0.202	0.521	0.210
Age	P < 0.001	P < 0.001	P < 0.001	P = 0.127	P = 0.042	P < 0.001	P = 0.096	P < 0.001	0.084
Lumb QCT	0.712	0.714	0.523	0.363	- 0.443	0.454	0.403	- 0.496	- 0.437
Trab vBMD	P < 0.001	P < 0.001	P < 0.001	P = 0.003	P < 0.001	P < 0.001	P = 0.001	P < 0.001	P < 0.001
Lumb QCT	0.336	0.336	0.027	0.356	- 0.367	0.135	0.151	- 0.102	- 0.162
Cort vBMD	P = 0.005	P = 0.005	P = 0.827	P = 0.003	P = 0.002	P = 0.276	P = 0.223	P = 0.410	P = 0.191
mSASSS	- 0.475	- 0.475	- 0.488	- 0.105	0.176	- 0.315	-0.161	0.363	0.169
	P < 0.001	P < 0.001	P < 0.001	P = 0.392	P = 0.148	P = 0.008	P = 0.186	P = 0.002	P = 0.169

BV/TV, trabecular bone volume fraction; Cort, cortical; DCort, vBMD of cortical peripheral bone; DTrab, vBMD of trabecular peripheral bone; CortTh, cortical thickness peripheral bone; CtPo, cortical porosity; CtPoDiam, mean cortical pore diameter; HRpQCT, high-resolution peripheral quantitative computed tomography; Lumb, lumbar; TbN, trabecular number peripheral bone; TbSp, trabecular separation peripheral bone; Tbth,trabecular thickness peripheral bone; Trab, trabecular; vBMD, volumetric bone mineral density; QCT, quantitative computed tomography.

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ISSN: 1478-6362

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