Proteomic profiling and functional characterization of early and late shoulder osteoarthritis

Table 1 Cytokine concentrations in synovial fluid from healthy subjects (n = 5, pooled), and patients with early- (n = 5) and late-stage (n = 5) osteoarthritis

Pro-inflammatory interleukins	Sample (n = 5)	Mean (pg/mL)	SD
IL-6	Healthy^a	98.35
	EOA	717.9	306.50
	LOA	1492.01	877.62
IL-1β	Healthy^a	0
	EOA	1.45	1.56
	LOA	4.64	3.29
IL-8	Healthy^a	0
	EOA	6.58	6.03
	LOA	38.63	10.35
IL-17A	Healthy^a	0
	EOA	0.02	0.05
	LOA	0	0
TNF-alpha	Healthy^a	0
	EOA	0.11	0.11
	LOA	0.51	0.63
IL-18	Healthy^a	0.48
	EOA	20.38	8.70
	LOA	37.29	15.36
Anti-inflammatory interleukins
IL-10	Healthy^a	1.68
	EOA	6.39	1.95
	LOA	7.97	3.35

The numeric values depicted for EOA and LOA samples are mean ± SD (concentration range). ^aCytokine concentrations depicted for healthy synovial fluid samples (n = 5) are values obtained from pooled samples. EOA, early osteoarthritis; LOA, late osteoarthritis.

ISSN: 1478-6362