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Table 2 Immunohistochemistry characteristics according to ACPA status

From: Differences in synovial fluid cytokine levels but not in synovial tissue cell infiltrate between anti-citrullinated peptide/protein antibody-positive and –negative rheumatoid arthritis patients

Synovial cells Total number = 83 ACPA positive number = 64 ACPA negative number = 19 P value
CD3/mm2 (Median, IQR 25 to 75) 509.90(210.7–821.6) n = 70 514.10 (198.9–821.6) N = 54 509.30 (233.8–898.2) n = 16 0.823
CD20/mm2 (Median, IQR 25 to 75) 126.52 (30.3–242.6) n = 70 117.90 (26.6–235.4) n = 54 162.73 (42.2–315) n = 16 0.386
CD20 cell grade 3 follicles (Median, IQR 25 to 75) 0 (0–2.7) n = 72 0 (0–2) n = 55 2.0 (0–3.5) n = 17 0.221
CD68L/mm2 (Median, IQR 25 to 75) 293.34 (94.2–453.4) n = 63 305.59 (94.2–438.5) n = 47 204.74 (93.5–532.2) n = 16 0.813
CD68SL/mm2 (Median, IQR 25 to 75) 677.17 (3.1–1665.5) n = 63 738.50 (379.3–2016.7) n = 47 526.74 (271.5–874.9) n = 16 0.138
CD15/mm2 (Median, IQR 25 to 75) 58.46 (10–204.4) n = 49 71.90 (9.0–445.4) n = 35 35.74 (9.9–88) n = 14 0.278
CD117/mm2 (Median, IQR 25 to 75) 40.26 (20.8–55) n = 51 39.27 (21.2–54.5) n = 37 42.81 (19.1–75.6) n = 14 0.473
CD31/34 (Median, IQR 25 to 75) 46.31 (37.4–64.1) n = 44 53.66 (36.8–68.8) n = 31 43.56 (34–63) n = 13 0.425
LN (%) 40.80 39.50 58.80 0.119
  1. ACPA, anti-citrullinated peptide/protein antibodies; IQR, interquatile range; LN, lymphoid neogenesis; n, number.