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Table 2 Immunohistochemistry characteristics according to ACPA status

From: Differences in synovial fluid cytokine levels but not in synovial tissue cell infiltrate between anti-citrullinated peptide/protein antibody-positive and –negative rheumatoid arthritis patients

Synovial cells

Total number = 83

ACPA positive number = 64

ACPA negative number = 19

P value

CD3/mm2 (Median, IQR 25 to 75)

509.90(210.7–821.6) n = 70

514.10 (198.9–821.6) N = 54

509.30 (233.8–898.2) n = 16

0.823

CD20/mm2 (Median, IQR 25 to 75)

126.52 (30.3–242.6) n = 70

117.90 (26.6–235.4) n = 54

162.73 (42.2–315) n = 16

0.386

CD20 cell grade 3 follicles (Median, IQR 25 to 75)

0 (0–2.7) n = 72

0 (0–2) n = 55

2.0 (0–3.5) n = 17

0.221

CD68L/mm2 (Median, IQR 25 to 75)

293.34 (94.2–453.4) n = 63

305.59 (94.2–438.5) n = 47

204.74 (93.5–532.2) n = 16

0.813

CD68SL/mm2 (Median, IQR 25 to 75)

677.17 (3.1–1665.5) n = 63

738.50 (379.3–2016.7) n = 47

526.74 (271.5–874.9) n = 16

0.138

CD15/mm2 (Median, IQR 25 to 75)

58.46 (10–204.4) n = 49

71.90 (9.0–445.4) n = 35

35.74 (9.9–88) n = 14

0.278

CD117/mm2 (Median, IQR 25 to 75)

40.26 (20.8–55) n = 51

39.27 (21.2–54.5) n = 37

42.81 (19.1–75.6) n = 14

0.473

CD31/34 (Median, IQR 25 to 75)

46.31 (37.4–64.1) n = 44

53.66 (36.8–68.8) n = 31

43.56 (34–63) n = 13

0.425

LN (%)

40.80

39.50

58.80

0.119

  1. ACPA, anti-citrullinated peptide/protein antibodies; IQR, interquatile range; LN, lymphoid neogenesis; n, number.