Differences in synovial fluid cytokine levels but not in synovial tissue cell infiltrate between anti-citrullinated peptide/protein antibody-positive and –negative rheumatoid arthritis patients

Table 3 Comparison of patients with SF cytokine analysis

Variables	Total number = 51	ACPA positive number = 40	ACPA negative N = 11	P value
Sex (female,%)	64.7	65.0	63.6	0.93
Age at arthroscopy, years (Mean, SD)	56.8 ± 12.1	58.5 ± 12.2	58.3 ± 1mber2.2	0.64
Disease duration to arthroscopy (months), Median (IQR 25–75)	52.0(12.2–134.3) N = 47	39.3 (8.7–134.3) N = 39	87.9(45.7–147.4) N = 8	0.32
Rheumatoid factor (%)	82	90	54	0.006*
Erosive disease (%)	72	72	70	0.87
Extra-articular disease (%)	37	40	25	0.41
DAS28, Median (IQR 25–75)	5.06 (3.9–5.8) N = 47	5.06 (4.0–5.7) N = 37	5.13 (3.8–5.9) N = 10	0.81
ESR mm/hr (before arthroscopy), Median (IQR 25–75)	43 (22–70) N = 47	43 (24–71) N = 37	27 (16–66) N = 10	0.42
CRP mg/dl (before arthroscopy), Median (IQR 25–75)	3.0 (1.2–6.2) N = 47	3.1 (1.1–6.6) N = 37	2.2 (1.1–6.3) N = 10	0.82
DMARDs (Mean, SD)	2.61 ± 1.50	2.43 ± 1.48	3.27 ± 1.60	0.10
Biologic treatment (%) ever	49	40	82	0.014*

Data are expressed as median (IQR) or as percentage. CRP, C-reactive protein; DMARDs, disease modifying anti-rheumatic drugs; ESR, erythrocyte sedimentation rate; mHAQ, Modified Health Assessment Questionnaire; IQR, interquartile range; SF, synovial fluid; SJC, swelling joint count; TJC, tender joint count. * p value is significant if < 0.05.

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