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Table 2 Top ten upregulated and downregulated genes comparing lateral tibial bone (below intact cartilage) with medial tibial bone (below lesioned cartilage)

From: Genome-wide expression profiles of subchondral bone in osteoarthritis

    

Fold-change (MT vs. LT)

Accession number

Gene symbol

Gene name

P valuea

OA (microarray)

Non-OA (microarray)

OA (qRT-PCR)

Genes with increased expression in medial tibial bone

  

  NM_000641

IL11

Interleukin-11

1.32 × 10–14

16.02

1.12

110.31*

  NM_006475

POSTN

Periostin, osteoblast specific factor

1.48 × 10–10

15.65

1.55

9.68*

  NM_017680

ASPN

Asporin

2.82 × 10–9

9.04

2.93

6.34*

  NM_057165

COL6A3

Collagen, type VI, alpha 3

9.65 × 10–10

8.27

1.33

5.11*

  NM_006086

TUBB3

Tubulin, beta 3

6.98 × 10–15

7.36

1.11

6.28*

  NM_000090

COL3A1

Collagen, type III, alpha 1

5.33 × 10–16

7.33

1.32

6.45*

  NM_033014

OGN

Osteoglycin

7.24 × 10–10

6.69

1.70

9.33*

  NM_013989

DIO2

Deiodinase, iodothyronine, type II

1.58 × 10–11

6.20

1.31

5.74*

  NM_006240

PPEF1

Protein phosphatase, EF-hand calcium binding domain 1

5.31 × 10–13

6.14

1.97

4.51*

  NM_003701

TNFSF11

Tumor necrosis factor (ligand) superfamily, member 11

1.21 × 10–11

5.90

1.07

2.64*

Genes with decreased expression in medial tibial bone

  NM_000230

LEP

Leptin

4.00 × 10–10

−23.27

−2.05

−18.99*

  NM_000384

APOB

Apolipoprotein B

3.31 × 10–10

−16.88

−2.12

−10.20*

  NM_000668

ADH1B

Alcohol dehydrogenase 1B (class I), beta polypeptide

2.27 × 10–7

−12.23

−1.95

NA

  NM_005623

CCL8

Chemokine (C–C motif) ligand 8

8.17 × 10–9

−10.50

−1.59

−6.00*

  NM_172367

TUSC5

Tumor suppressor candidate 5

4.22 × 10–10

−10.25

−1.89

−8.19*

  NM_175737

KLB

Klotho beta

2.24 × 10–8

−10.00

−1.63

−6.09*

  NM_001204375

NPR3

Natriuretic peptide receptor C

1.36 × 10–10

−9.95

−1.38

−7.81*

  NM_002666

PLIN1

Perilipin 1

2.98 × 10–8

−9.60

−1.81

−5.88*

  NM_002591

PCK1

Phosphoenolpyruvate carboxykinase 1

1.03 × 10–9

−9.01

−1.87

−5.44*

  NM_001198950

MYO16

Myosin XVI

5.81 × 10–7

−8.84

−1.93

NA

  1. LT, lateral tibial; MT, medial tibial; NA, not analyzed; OA, osteoarthritis. aAdjusted P value for microarray corrected for multiple testing by the Benjamini–Hochberg method. *P <0.001 for quantitative reverse-transcription polymerase chain reaction (qRT-PCR), comparing OA MT versus OA LT. P values were determined by two-tailed unpaired Student’s t test.
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Arthritis Research & Therapy

ISSN: 1478-6362

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