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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Cytokine signaling-1 suppressor is inducible by IL-1beta and inhibits the catabolic effects of IL-1beta in chondrocytes: its implication in the paradoxical joint-protective role of IL-1beta

Figure 1

Expression of SOCS1 in osteoarthritic cartilage. Cartilage samples from four patients with femoral neck fracture and six with knee OA were immune-stained, as described in Methods. No to minimal SOCS1 expression was observed in healthy cartilage, whereas the intensity of SOCS1 expression and the number of SOCS1-positive cells increased in OA cartilage, especially in areas of severe cartilage damage (A, original magnification × 200). SOCS1 was localized in the cytoplasm and nucleus (B, original magnification × 200). The percentage of SOCS1-expressing chondrocytes was significantly higher in the severe OA lesions as compared with mild OA and healthy cartilage (C; P < 0.01). Data were expressed as the means ± SEM. *Corrected P < 0.05 by Mann–Whitney test with Bonferroni correction.

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Arthritis Research & Therapy

ISSN: 1478-6362

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