The inclusion of N-terminal pro-brain natriuretic peptide in a sensitive screening strategy for systemic sclerosis-related pulmonary arterial hypertension: a cohort study

Table 3 Comparison of investigation parameters between groups

Investigations	PAH	No PH	LHD-PH	ILD-PH	P value*
TTE parameters
TRV (m/s)	3.5 ± 0.3	2.8 ± 0.4	3.2 ± 0.3	3.4 ± 0.4	<0.0001
sPAP (mmHg)	57.7 ± 11.1	38.0 ± 9.9	48.5 ± 10.5	56.8 ± 15.6	<0.0001
RHC results
mPAP (mmHg)	34.9 ± 6.9	19.0 ± 3.7	32.0 ± 4.5	32.2 ± 7.3	<0.0001
mRAP (mmHg)	9.6 ± 4.0	5.7 ± 3.3	8.5 ± 3.4	7.2 ± 4.0	0.006
PVR (Wood units)	5.2 ± 2.9	1.6 ± 0.9	2.1 ± 0.8	5.3 ± 3.5	0.0004
PFT results
FVC (% pred)	91.8 ± 15.1	87.0 ± 26.5	86.5 ± 6.5	49.0 ± 15.0	0.481
DLCO _corr (% pred)	45.9 ± 11.6	61.3 ± 15.6	59.6 ± 17.7	30.7 ± 9.8	0.001
6MWD (m)	290 ± 117	421 ± 119	394 ± 95	330 ± 117	0.004
FVC/DLCO _corr	2.1 ± 0.5	1.45 ± 0.4	1.6 ± 0.5	2.0 ± 0.8	0.0001
NT-proBNP (pg/mL)	1,074 ± 1,506	303 ± 461	288 ± 159.9	3,367 ± 3,337	0.0075

*Statistical comparisons were made between PAH and no PH groups only, due to the small size of the LHD-PH and ILD-PH groups. PAH, pulmonary arterial hypertension; PH, pulmonary hypertension; LHD, left heart disease; ILD, interstitial lung disease; TRV, tricuspid regurgitant velocity; sPAP, systolic pulmonary artery; mPAP, mean pulmonary artery pressure; mRAP, mean right atrial pressure; PVR, pulmonary vascular resistance; FVC, forced vital capacity (% predicted); DLCO, diffusion capacity of lung for carbon monoxide (% predicted); 6MWD, six-minute walk distance; NT-proBNP, N-terminal pro-brain natriuretic peptide.

ISSN: 1478-6362