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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Immune response profiling in early rheumatoid arthritis: discovery of a novel interaction of treatment response with viral immunity

Figure 3

Clinical improvement in the DAS28 related to methotrexate treatment compared to other disease-modifying antirheumatic drugs is uniquely associated with up-regulation of the cytomegalovirus/Epstein-Barr virus (CMV/EBV) immune-response signature. Shown are box plots comparing the changes in the CMV/EBV PCA-1 score from baseline to 21 to 24 weeks of follow up among 43 patients with early rheumatoid arthritis among no MTX/non-responders (n = 13), no MTX/responders (n = 10), MTX/non-responders (n = 7), and MTX/responders (n = 13). The horizontal center lines indicate the medians, the boxes represent the interquartile ranges, and the whiskers depict the 2.5 and 97.5 percentiles. DAS28, disease activity score in 28 joints; PCA-1 score, principal components analysis-1 score; MTX, methotrexate.

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Arthritis Research & Therapy

ISSN: 1478-6362

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