Immune response profiling in early rheumatoid arthritis: discovery of a novel interaction of treatment response with viral immunity

Table 5 Association of the changes in the immune response profiles with the changes in clinical disease activity and disability from baseline to 21 to 24 weeks of follow up in 43 patients with RA

Shown are the Spearman correlation coefficients and associated P-values for the PCA stimulus-cytokine scores for the first and second principal components and both the change in the DAS28 and the change in HAQ from baseline to 21 to 24 weeks among 43 patients with early RA. ^aAdjusted for age, sex, body mass index, smoking status, rheumatoid factor status, anti-citrullinated protein antibodies status, CMV immunoglobulin G status, methotrexate use, and prednisone use; ^bvalues are statistically significant. ACR, American College of Rheumatology; DAS28, Disease Activity Score in 28 joints; CMV/EBV, cytomegalovirus/Epstein-Barr virus; PHA, phytohemagglutinin; HAQ-DI, Health Assessment Questionnaire disability index.

ISSN: 1478-6362