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Table 1 Baseline and stress-induced cytokine levels (pg/ml) in the intervention and control conditions post treatment and at follow-up

From: Immune responses to stress after stress management training in patients with rheumatoid arthritis

Ā Ā 

t= 0 minutes

t= 20 minutes

t= 40 minutes

t= 80 minutes

IL-1Ī²

Ā Ā Ā Ā Ā 

ā€ƒPost-treatment

IC

92.39 (33.6)

106.7 (41.4)

111.3 (46.4)

111.6 (45.4)

Ā 

CC

114.3 (38.6)

130.9 (43.5)

116.6 (37.0)

136.7 (59.0)

ā€ƒFollow-up

IC

66.48 (18.8)

77.43 (23.7)

69.49 (20.1)

70.89 (19.9)

Ā 

CC

119.0 (43.0)

100.7 (32.5)

98.13 (34.1)

117.6 (41.2)

IL-2

Ā Ā Ā Ā Ā 

ā€ƒPost-treatment

IC

28.11 (11.1)

30.85 (11.9)

34.83 (15.6)

31.58 (13.4)

Ā 

CC

32.60 (14.0)

42.86 (19.2)

38.77 (17.3)

47.51 (27.0)

ā€ƒFollow-up

IC

20.28 (7.20)

25.27 (10.3)

17.37 (7.23)

19.32 (7.15)

Ā 

CC

35.89 (18.4)

27.82 (14.1)

28.12 (14.0)

32.24 (15.4)

IL-4

Ā Ā Ā Ā Ā 

ā€ƒPost-treatment

IC

48.22 (24.9)

48.30 (21.0)

48.98 (20.3)

52.90 (25.7)

Ā 

CC

60.18 (29.3)

72.79 (30.1)

65.76 (28.4)

65.39 (29.9)

ā€ƒFollow-up

IC

33.22 (13.9)

35.16 (14.9)

33.62 (12.6)

33.08 (13.6)

Ā 

CC

56.48 (23.2)

51.79 (20.0)

50.91 (21.5)

56.99 (24.8)

IL-5

Ā Ā Ā Ā Ā 

ā€ƒPost-treatment

IC

20.94 (15.2)

21.89 (15.3)

23.24 (16.5)

21.49 (15.6)

Ā 

CC

5.129 (2.17)

7.887 (3.72)

7.006 (2.94)

8.948 (4.51)

ā€ƒFollow-up

IC

16.23 (12.8)

15.89 (12.1)

15.14 (12.1)

17.60 (14.5)

Ā 

CC

7.368 (3.48)

6.048 (2.95)

5.929 (2.60)

6.969 (3.11)

IL-6

Ā Ā Ā Ā Ā 

ā€ƒPost-treatment

IC

36.46 (11.2)

34.94 (9.69)

38.80 (11.1)

40.36 (11.2)

Ā 

CC

30.18 (9.36)

41.18 (15.2)

33.54 (10.7)

39.57 (16.2)

ā€ƒFollow-up

IC

25.79 (7.51)

23.39 (7.90)

23.63 (6.41)

23.18 (6.68)

Ā 

CC

31.20 (14.1)

30.18 (12.0)

29.22 (11.3)

30.43 (11.6)

IL-7

Ā Ā Ā Ā Ā 

ā€ƒPost-treatment

IC

70.11 (26.0)

70.27 (24.8)

73.62 (24.7)

69.51 (27.2)

Ā 

CC

52.69 (16.5)

63.65 (20.5)

55.94 (18.5)

60.73 (21.8)

ā€ƒFollow-up

IC

52.54 (23.4)

54.54 (23.5)

49.13 (19.6)

53.32 (22.2)

Ā 

CC

52.80 (18.4)

53.69 (18.0)

48.64 (18.2)

52.89 (19.1)

IL-8

Ā Ā Ā Ā Ā 

ā€ƒPost-treatment

IC

22.14 (3.67)

16.19 (3.70)

17.02 (3.53)

14.47 (3.41)

Ā 

CC

29.55 (6.50)

34.04 (7.81)

29.45 (6.75)

28.18 (7.14)

ā€ƒFollow-up

IC

19.51 (4.28)

13.97 (4.67)

12.53 (4.00)

10.37 (3.38)a

Ā 

CC

33.63 (6.68)

33.46 (8.33)

29.31 (7.83)

23.64 (5.72)

IL-10

Ā Ā Ā Ā Ā 

ā€ƒPost-treatment

IC

172.0 (75.2)

183.7 (81.0)

175.5 (80.0)

164.7 (75.8)

Ā 

CC

49.33 (25.9)

57.07 (31.8)

73.55 (48.1)

71.02 (45.9)

ā€ƒFollow-up

IC

72.67 (35.6)

115.6 (54.6)

85.90 (41.9)

78.49 (37.4)

Ā 

CC

46.83 (26.8)

43.63 (24.2)

39.90 (20.9)

50.27 (28.0)

IFNĪ³

Ā Ā Ā Ā Ā 

ā€ƒPost-treatment

IC

1.063 (0.39)

1.070 (0.43)

0.821 (0.33)

0.706 (0.31)

Ā 

CC

1.545 (0.45)

8.328 (4.98)

6.623 (4.91)

7.591 (5.70)

ā€ƒFollow-up

IC

0.857 (0.39)

0.772 (0.32)

0.925 (0.36)

1.062 (0.38)

Ā 

CC

4.389 (2.87)

8.535 (6.37)

6.597 (4.98)

7.377 (5,94)

TNFĪ±

Ā Ā Ā Ā Ā 

ā€ƒPost-treatment

IC

31.40 (8.54)

34.98 (8.95)

34.82 (8.35)

35.60 (10.7)

Ā 

CC

34.56 (12.4)

39.35 (12.7)

36.00 (11.1)

35.45 (11.2)

ā€ƒFollow-up

IC

23.90 (5.75)

26.44 (6.94)

24.74 (5.89)

25.19 (6.44)

Ā 

CC

26.26 (8.74)

23.84 (7.17)

25.04 (9.44)

25.93 (8.92)

  1. Data presented as mean (Ā± standard error of the mean). CC, control condition; IC, intervention condition; IFNĪ³, interferon gamma; IL, interleukin; TNFĪ±, tumor necrosis factor alpha. aSignificant between-group effect (P ā‰¤0.05). Means at the four time points. Statistical analyses performed on ln-transformed data.