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Table 2 Gastroduodenal histological findings and genetic and serological markers a

From: Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study

Cohorts

IBS (N = 125)

IBS/FMS (N = 104)

P value

Gastroduodenal biopsy

 IEL count per 100 epithelial cells

15 (10)

27 (26)

<0.001

 Marsh stage 0

105 (84)

39 (37)

<0.001

 Marsh stage 1

20 (16)

58 (56)

<0.001

 Marsh stage 3

2 (2)

7 (7)

<0.001

 Helicobacter pylori (+)

58 (46)

44 (42)

0.080

CD laboratory biomarkers

 HLA-DQ2 A1/B1 (+)

30 (24)

52 (50)

<0.001

 IgA anti-tTG-2 serum levels, U/ml

0.4 (0.1)

4.7 (20)

<0.001

  1. aCD, coeliac disease; HLA, major histocompatibility complex class II human leucocyte antigen; IBS, irritable bowel syndrome; IBS/FMS, irritable bowel syndrome plus fibromyalgia syndrome; IEL, intraepithelial lymphocyte count per 100 epithelial cells in duodenal biopsy sample; IgA, immunoglobulin A; tTG, tissue transglutaminase. Data are expressed as total and percentage of the total value or as mean and standard deviation.