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Table 2 Gastroduodenal histological findings and genetic and serological markers a

From: Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study

Cohorts IBS (N = 125) IBS/FMS (N = 104) P value
Gastroduodenal biopsy
 IEL count per 100 epithelial cells 15 (10) 27 (26) <0.001
 Marsh stage 0 105 (84) 39 (37) <0.001
 Marsh stage 1 20 (16) 58 (56) <0.001
 Marsh stage 3 2 (2) 7 (7) <0.001
Helicobacter pylori (+) 58 (46) 44 (42) 0.080
CD laboratory biomarkers
 HLA-DQ2 A1/B1 (+) 30 (24) 52 (50) <0.001
 IgA anti-tTG-2 serum levels, U/ml 0.4 (0.1) 4.7 (20) <0.001
  1. aCD, coeliac disease; HLA, major histocompatibility complex class II human leucocyte antigen; IBS, irritable bowel syndrome; IBS/FMS, irritable bowel syndrome plus fibromyalgia syndrome; IEL, intraepithelial lymphocyte count per 100 epithelial cells in duodenal biopsy sample; IgA, immunoglobulin A; tTG, tissue transglutaminase. Data are expressed as total and percentage of the total value or as mean and standard deviation.