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Table 4 Main symptoms, associated diseases, tender points and test scores a

From: Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study

Symptoms and diseases IBS IBS/FMS P value IBS/FMS cases classified by Marsh stage P value
  (N = 125) (N = 104) (IBS vs. FMS) Marsh stage 0 (N = 39) Marsh stage 1 (N = 58) Marsh stage 3 (N = 7) (Marsh stages 1 and 3 vs. Marsh stage 0)
Widespread pain 104 (100) NA 39 (100) 58 (100) 7 (100) 1.000
Digestive complaints 125 (100) 104 (100) 1.000 39 (100) 58 (100) 7 (100) 1.000
Fatigue 31 (25) 94 (90) <0.001 35 (90) 53 (91) 6 (86) 0.878
Sleep disturbances 28 (22) 87 (84) <0.001 29 (74) 52 (89) 6 (86) 0.134
Anxiety/depression 77 (62) 69 (66) 0.273 22 (56) 42 (72) 5 (71) 0.251
Skin problemsb 31 (25) 52 (50) <0.001 20 (51) 28 (48) 4 (57) 0.888
Cognitive dysfunction 5 (4) 37 (36) <0.001 14 (36) 20 (34) 3 (43) 0.908
Urinary urgency 6 (5) 30 (29) <0.001 10 (26) 18 (31) 2 (29) 0.848
Headachesc 24 (19) 29 (28) 0.082 5 (13) 21 (36) 3 (43) 0.028
Balance problems/dizziness 9 (7) 29 (28) <0.001 10 (26) 17 (29) 2 (29) 0.924
Joint stiffness 2 (2) 27 (26) <0.001 9 (23) 16 (28) 2 (29) 0.872
Paraesthesias 4 (3) 25 (24) <0.001 9 (23) 14 (24) 2 (29) 0.952
Osteoporosis 7 (6) 14 (13) 0.034 2 (5) 10 (17) 2 (29) 0.110
TMJ disorder 13 (12) NA 5 (13) 6 (10) 2 (29) 0.520
Restless legs syndrome 13 (12) NA 3 (8) 8 (14) 1 (14) 0.277
Sjögren syndrome 8 (8) NA 7 (12) 1 (14) NA
Raynaud syndrome 1 (1) 5 (5) 0.069 5 (9) 1 (14) NA
Tender points (scale 0 to 18) 16.1 (1.9) NA 14.8 (1.2) 16.9 (1.8) 16.3 (2.4) <0.001
FIQ score (scale 0 to 80) 68 (9) NA 63 (7) 70 (9) 74 (3) <0.001
HAQ score (scale 0 to 3) 1.5 (0.6) NA 1.4 (0.5) 1.6 (0.6) 1.7 (0.6) 0.298
SF-36 Physical Component (scale 0 to 100) 44 (13) 29 (5) <0.001 30 (7) 29 (1) 27 (4) 0.380
SF-36 Mental Component (scale 0 to 100) 41 (13) 29 (14) <0.001 35 (10) 25 (13) 17 (4) <0.001
VAS fatigue score (scale 0 to 10) 3 (1) 7 (2) <0.001 7 (0.8) 8 (1.5) 8 (0.3) 0.006
VAS digestive score (scale 0 to 100) 31 (12) 47 (8) <0.001 46 (9) 47 (9) 48 (2) 0.516
Gastrointestinal symptoms duration, years 29 (5) 29 (7) 0.917 29 (5) 29 (8) 28 (9) 0.905
Extraintestinal systemic symptom duration, years 9 (2) NA 9 (2) 9 (2) 7 (4) 0.813
  1. aFIQ, Fibromyalgia Impact Questionnaire; HAQ, Health Assessment Questionnaire; IBS, inflammatory bowel syndrome; IBS/FMS, inflammatory bowel syndrome/fibromyalgia syndrome; NA, not applicable; SF-36, 36-Item Short Form Health Survey; TMJ = temporomandibular joint; VAS, Visual Analogue Scale. bSkin problems included itchy, dry or burning skin; chronic urticaria; and one case of dermatitis herpetiformis that was classified as Marsh stage 3. cHeadaches included migraine, tension and mixed headache syndrome. Data are expressed as total and percentage of total values or mean and standard deviation.