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Table 4 Main symptoms, associated diseases, tender points and test scores a

From: Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study

Symptoms and diseases

IBS

IBS/FMS

P value

IBS/FMS cases classified by Marsh stage

P value

 

(N = 125)

(N = 104)

(IBS vs. FMS)

Marsh stage 0 (N = 39)

Marsh stage 1 (N = 58)

Marsh stage 3 (N = 7)

(Marsh stages 1 and 3 vs. Marsh stage 0)

Widespread pain

–

104 (100)

NA

39 (100)

58 (100)

7 (100)

1.000

Digestive complaints

125 (100)

104 (100)

1.000

39 (100)

58 (100)

7 (100)

1.000

Fatigue

31 (25)

94 (90)

<0.001

35 (90)

53 (91)

6 (86)

0.878

Sleep disturbances

28 (22)

87 (84)

<0.001

29 (74)

52 (89)

6 (86)

0.134

Anxiety/depression

77 (62)

69 (66)

0.273

22 (56)

42 (72)

5 (71)

0.251

Skin problemsb

31 (25)

52 (50)

<0.001

20 (51)

28 (48)

4 (57)

0.888

Cognitive dysfunction

5 (4)

37 (36)

<0.001

14 (36)

20 (34)

3 (43)

0.908

Urinary urgency

6 (5)

30 (29)

<0.001

10 (26)

18 (31)

2 (29)

0.848

Headachesc

24 (19)

29 (28)

0.082

5 (13)

21 (36)

3 (43)

0.028

Balance problems/dizziness

9 (7)

29 (28)

<0.001

10 (26)

17 (29)

2 (29)

0.924

Joint stiffness

2 (2)

27 (26)

<0.001

9 (23)

16 (28)

2 (29)

0.872

Paraesthesias

4 (3)

25 (24)

<0.001

9 (23)

14 (24)

2 (29)

0.952

Osteoporosis

7 (6)

14 (13)

0.034

2 (5)

10 (17)

2 (29)

0.110

TMJ disorder

–

13 (12)

NA

5 (13)

6 (10)

2 (29)

0.520

Restless legs syndrome

–

13 (12)

NA

3 (8)

8 (14)

1 (14)

0.277

Sjögren syndrome

–

8 (8)

NA

–

7 (12)

1 (14)

NA

Raynaud syndrome

1 (1)

5 (5)

0.069

–

5 (9)

1 (14)

NA

Tender points (scale 0 to 18)

–

16.1 (1.9)

NA

14.8 (1.2)

16.9 (1.8)

16.3 (2.4)

<0.001

FIQ score (scale 0 to 80)

–

68 (9)

NA

63 (7)

70 (9)

74 (3)

<0.001

HAQ score (scale 0 to 3)

–

1.5 (0.6)

NA

1.4 (0.5)

1.6 (0.6)

1.7 (0.6)

0.298

SF-36 Physical Component (scale 0 to 100)

44 (13)

29 (5)

<0.001

30 (7)

29 (1)

27 (4)

0.380

SF-36 Mental Component (scale 0 to 100)

41 (13)

29 (14)

<0.001

35 (10)

25 (13)

17 (4)

<0.001

VAS fatigue score (scale 0 to 10)

3 (1)

7 (2)

<0.001

7 (0.8)

8 (1.5)

8 (0.3)

0.006

VAS digestive score (scale 0 to 100)

31 (12)

47 (8)

<0.001

46 (9)

47 (9)

48 (2)

0.516

Gastrointestinal symptoms duration, years

29 (5)

29 (7)

0.917

29 (5)

29 (8)

28 (9)

0.905

Extraintestinal systemic symptom duration, years

–

9 (2)

NA

9 (2)

9 (2)

7 (4)

0.813

  1. aFIQ, Fibromyalgia Impact Questionnaire; HAQ, Health Assessment Questionnaire; IBS, inflammatory bowel syndrome; IBS/FMS, inflammatory bowel syndrome/fibromyalgia syndrome; NA, not applicable; SF-36, 36-Item Short Form Health Survey; TMJ = temporomandibular joint; VAS, Visual Analogue Scale. bSkin problems included itchy, dry or burning skin; chronic urticaria; and one case of dermatitis herpetiformis that was classified as Marsh stage 3. cHeadaches included migraine, tension and mixed headache syndrome. Data are expressed as total and percentage of total values or mean and standard deviation.