TY - JOUR AU - Daoussis, Dimitrios AU - Liossis, Stamatis-Nick C. PY - 2013 DA - 2013/11/28 TI - B cells tell scleroderma fibroblasts to produce collagen JO - Arthritis Research & Therapy SP - 125 VL - 15 IS - 6 AB - In fibrosis fibroblasts are activated and overproduce collagen in a process with unknown drivers and equally unknown brakes that recently implicated a novel and surprising player, the B cell. B cells may be crucially involved in fibrosis in several ways: B cells may produce autoantibodies that can directly stimulate fibroblasts; B cells can produce profibrotic cytokines such as IL-6 or transforming growth factor beta; and, finally, B cells could directly stimulate fibroblasts by a contact-dependent mechanism. Recent experimental evidence suggests that B cells can enhance collagen production by fibroblasts, by a contact-dependent mechanism, and therefore are profibrotic ex vivo. These data strengthen the rationale of pursuing B-cell targeting therapies in systemic sclerosis. SN - 1478-6354 UR - https://doi.org/10.1186/ar4392 DO - 10.1186/ar4392 ID - Daoussis2013 ER -