TY - JOUR AU - Buhrmann, Constanze AU - Shayan, Parviz AU - Aggarwal, Bharat B. AU - Shakibaei, Mehdi PY - 2013 DA - 2013/11/28 TI - Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes JO - Arthritis Research & Therapy SP - R202 VL - 15 IS - 6 AB - Inflammatory cytokines play a key role in the pathogenesis of joint diseases such as rheumatoid arthritis (RA). Current therapies target mainly tumor necrosis factor α (TNF-α) as this has proven benefits. However, a large number of patients do not respond to or become resistant to anti-TNF-α therapy. While the role of TNF-α in RA is quite evident, the role of TNF-β, also called lymphotoxin-α (LT-α), is unclear. In this study we investigated whether TNF-β and its receptor play a role in chondrocytes in the inflammatory environment. SN - 1478-6354 UR - https://doi.org/10.1186/ar4393 DO - 10.1186/ar4393 ID - Buhrmann2013 ER -