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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Contact activation products are new potential biomarkers to evaluate the risk of thrombotic events in systemic lupus erythematosus

Figure 2

A reciprocal relationship exists between the generation of FXIIa-antithrombin (AT) and FXIIa-C1 inhibitor (C1INH) in clotting plasma. Citrated plasma from healthy donors, with and without the addition of calcium, was incubated in glass tubes, which elicits FXII activation on the glass surface. The levels of FXIIa-C1INH (A), FXIIa-AT (B), FXIa-C1INH (C), and FXIa-AT (D) were analyzed by sandwich ELISA. Each line connects data from one individual (n = 6), and statistical significance was determined using Wilcoxon’s signed-rank test.

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