Figure 8

PDL241 treatment reduced the severity of joint-related disease parameters in a rhesus CIA model. Analyses are provided for ‘all animals’ and animals with ‘early CRP onset’ as described in the Methods section. Collagen type II-specific IgM (A) and IgG (B) were measured by ELISA. (C) The small joint swelling score is a representation of the number of joints affected (joints with soft tissues swelling) and the severity of swelling for each individual joint. Urinary excretion of the collagen crosslinks (D) hydroxylysylpyrridinoline (HP) and (E) lysylpyrridinoline (LP) was determined, with the levels normalized to creatinine levels (nmol levels per mmol creatinine) to compensate for a possible dilution by spilled drinking water. Pl = Placebo, 30 = 30 mg/kg and 100 = 100 mg/kg. * P ≤0.05; ** P ≤0.01. CIA, collagen-induced arthritis; CRP, C-reactive protein; Ig, immunoglobulin.