Serum level of adiponectin is a surrogate independent biomarker of radiographic disease progression in early rheumatoid arthritis: results from the ESPOIR cohort

Table 2 Unadjusted and adjusted association of serum adipokine levels and total joint erosive and narrowing Sharp/van der Heijde score (SHS) at inclusion for RA patients with SHS ≥1 ( n = 446)

		Univariate		Model 1 “Base”		Model 2 “metabolic”		Model 3 “metabolic + RA”		Model 4 “metabolic + RA + steroid”
		β	P	β	P	β	P	β	P	β	p
Adiponectin	Total SHS	0.058	0.1	0.097	0.007	0.1	0.006	0.11	0.007	0.12	0.006
	Erosive SHS	-0.004	0.93	0.035	0.40	0.03	0.52	0.06	0.22	0.06	0.22
	Narrowing SHS	0.097	0.03	0.1	0.02	0.13	0.006	0.14	0.009	0.14	0.01
Leptin	Total SHS	0.015	0.75	0.015	0.73	-0.01	0.79	-0.01	0.76	-0.01	0.74
	Erosive SHS	-0.15	0.005	-0.13	0.01	-0.09	0.02	-0.06	0.14	-0.07	0.13
	Narrowing SHS	0.13	0.02	0.11	0.047	0.04	0.40	0.02	0.64	0.03	0.63
Visfatin/NAMPT	Total SHS	0.006	0.89	0.008	0.87	-0.01	0.82	-0.04	0.46	-0.04	0.46
Visfatin/NAMPT	Erosive SHS	-0.08	0.11	-0.1	0.06	-0.12	0.03	-0.14	0.02	-0.14	0.02
	Narrowing SHS	-0.004	0.95	0.02	0.70	-0.009	0.89	-0.02	0.71	-0.02	0.71

Multivariate models: Model 1 (“base”): sex + age. Model 2 (“metabolic”): Model 1 + BMI + HOMA-IR index. Model 3 (“metabolic + RA”): Model 2 + CRP level + DAS28-ESR value + HAQ score + RF status + anti-CCP antibody status. Model 4 (“metabolic + RA + steroid”): Model 3 + steroid prescription at inclusion. The following variables were log-transformed: CRP level, HAQ score, serum adipokine levels. Results are presented as β regression coefficient and P value. Bold P values are significant.