| |
Univariate
|
Model 1 “Base”
|
Model 2 “metabolic”
|
Model 3 “metabolic + RA”
|
Model 4 “metabolic + RA + steroid”
|
|---|
|
β
|
P
|
β
|
P
|
β
|
P
|
β
|
P
|
β
|
p
|
|---|
|
Adiponectin
|
Total SHS
|
0.058
|
0.1
|
0.097
|
0.007
|
0.1
|
0.006
|
0.11
|
0.007
|
0.12
|
0.006
|
|
Erosive SHS
|
-0.004
|
0.93
|
0.035
|
0.40
|
0.03
|
0.52
|
0.06
|
0.22
|
0.06
|
0.22
|
|
Narrowing SHS
|
0.097
|
0.03
|
0.1
|
0.02
|
0.13
|
0.006
|
0.14
|
0.009
|
0.14
|
0.01
|
|
Leptin
|
Total SHS
|
0.015
|
0.75
|
0.015
|
0.73
|
-0.01
|
0.79
|
-0.01
|
0.76
|
-0.01
|
0.74
|
|
Erosive SHS
|
-0.15
|
0.005
|
-0.13
|
0.01
|
-0.09
|
0.02
|
-0.06
|
0.14
|
-0.07
|
0.13
|
|
Narrowing SHS
|
0.13
|
0.02
|
0.11
|
0.047
|
0.04
|
0.40
|
0.02
|
0.64
|
0.03
|
0.63
|
|
Visfatin/NAMPT
|
Total SHS
|
0.006
|
0.89
|
0.008
|
0.87
|
-0.01
|
0.82
|
-0.04
|
0.46
|
-0.04
|
0.46
|
|
Erosive SHS
|
-0.08
|
0.11
|
-0.1
|
0.06
|
-0.12
|
0.03
|
-0.14
|
0.02
|
-0.14
|
0.02
|
| |
Narrowing SHS
|
-0.004
|
0.95
|
0.02
|
0.70
|
-0.009
|
0.89
|
-0.02
|
0.71
|
-0.02
|
0.71
|
- Multivariate models: Model 1 (“base”): sex + age. Model 2 (“metabolic”): Model 1 + BMI + HOMA-IR index. Model 3 (“metabolic + RA”): Model 2 + CRP level + DAS28-ESR value + HAQ score + RF status + anti-CCP antibody status. Model 4 (“metabolic + RA + steroid”): Model 3 + steroid prescription at inclusion. The following variables were log-transformed: CRP level, HAQ score, serum adipokine levels. Results are presented as β regression coefficient and P value. Bold P values are significant.
