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Table 2 Unadjusted and adjusted association of serum adipokine levels and total joint erosive and narrowing Sharp/van der Heijde score (SHS) at inclusion for RA patients with SHS ≥1 ( n= 446)

From: Serum level of adiponectin is a surrogate independent biomarker of radiographic disease progression in early rheumatoid arthritis: results from the ESPOIR cohort

  Univariate Model 1 “Base” Model 2 “metabolic” Model 3 “metabolic + RA” Model 4 “metabolic + RA + steroid”
β P β P β P β P β p
Adiponectin Total SHS 0.058 0.1 0.097 0.007 0.1 0.006 0.11 0.007 0.12 0.006
Erosive SHS -0.004 0.93 0.035 0.40 0.03 0.52 0.06 0.22 0.06 0.22
Narrowing SHS 0.097 0.03 0.1 0.02 0.13 0.006 0.14 0.009 0.14 0.01
Leptin Total SHS 0.015 0.75 0.015 0.73 -0.01 0.79 -0.01 0.76 -0.01 0.74
Erosive SHS -0.15 0.005 -0.13 0.01 -0.09 0.02 -0.06 0.14 -0.07 0.13
Narrowing SHS 0.13 0.02 0.11 0.047 0.04 0.40 0.02 0.64 0.03 0.63
Visfatin/NAMPT Total SHS 0.006 0.89 0.008 0.87 -0.01 0.82 -0.04 0.46 -0.04 0.46
Erosive SHS -0.08 0.11 -0.1 0.06 -0.12 0.03 -0.14 0.02 -0.14 0.02
  Narrowing SHS -0.004 0.95 0.02 0.70 -0.009 0.89 -0.02 0.71 -0.02 0.71
  1. Multivariate models: Model 1 (“base”): sex + age. Model 2 (“metabolic”): Model 1 + BMI + HOMA-IR index. Model 3 (“metabolic + RA”): Model 2 + CRP level + DAS28-ESR value + HAQ score + RF status + anti-CCP antibody status. Model 4 (“metabolic + RA + steroid”): Model 3 + steroid prescription at inclusion. The following variables were log-transformed: CRP level, HAQ score, serum adipokine levels. Results are presented as β regression coefficient and P value. Bold P values are significant.