
Univariate model

Model 1 “Base”

Model 2 “Metabolic”

Model 3 “Metabolic + RA”

Model 4 “Metabolic + RA + steroid”


OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P


Adiponectin

Total ∆SHS ≥1

1.34 (1.031.76)

0.03

1.59 (1.192.12)

0.002

1.57 (1.162.13)

0.004

1.84 (1.242.71)

0.002

1.84 (1.252.72)

0.002

Erosive ∆SHS ≥1

1.34 (1.021.75)

0.03

1.56 (1.172.08)

0.003

1.54 (1.132.08)

0.006

1.73 (1.172.55)

0.006

1.73 (1.172.55)

0.006

Narrowing ∆SHS ≥1

1.65 (1.052.61)

0.03

1.79 (1.102.90)

0.02

1.95 (1.163.27)

0.01

1.91 (1.043.52)

0.04

1.93 (1.043.57)

0.04

Leptin

Total ∆SHS ≥1

0.86 (0.711.05)

0.14

0.95 (0.761.18)

0.63

1.24 (0.91.70)

0.2

1.59 (1.052.41)

0.03

1.59 (1.052.42)

0.03

Erosive ∆SHS ≥1

0.88 (0.721.07)

0.19

0.96 (0.771.20)

0.69

1.29 (0.931.78)

0.12

1.68 (1.112.56)

0.01

1.69 (1.112.57)

0.01

Narrowing ∆SHS ≥1

0.93 (0.661.3)

0.66

0.93 (0.641.35)

0.70

1.09 (0.631.87)

0.76

1.1 (0.582.09)

0.76

1.10 (0.582.08)

0.77

Visfatin/NAMPT

Total ∆SHS ≥1

1.22 (0.991.51)

0.06

1.20 (0.971.49)

0.09

1.2 (0.951.49)

0.12

1.09 (0.811.46)

0.57

1.09 (0.811.46)

0.58

Erosive ∆SHS ≥1

1.25 (1.011.54)

0.04

1.23 (0.991.52)

0.06

1.22 (0.981.53)

0.08

1.14 (0.851.53)

0.37

1.14 (0.851.54)

0.37


Narrowing ∆SHS ≥1

1.17 (0.821.67)

0.39

1.16 (0.811.67)

0.41

1.05 (0.731.53)

0.79

1.12 (0.721.75)

0.62

1.13 (0.721.77)

0.6

 OR, odds ratio; 95% CI, 95% confidence interval. Total patient number, 530.
 Data are unadjusted and adjusted odds ratios with p values. Bold P values are significant.
 Radiographic progression is defined as variation in total SHS between inclusion and 1 year (total ∆SHS) ≥1.
 Erosive radiographic progression is defined as variation in erosive SHS between inclusion and 1 year (erosive ∆SHS ≥1).
 Narrowing radiographic progression is defined as variation in narrowing SHS between inclusion and 1 year (narrowing ∆SHS ≥1).
 Multivariate models:
 Model 1 (“base”): sex + age (n = 530).
 Model 2 (“metabolic”): Model 1 + BMI + HOMAIR index (n = 497).
 Model 3 (“metabolic + RA”): Model 2 + CRP level + DAS28ESR value + HAQ score + RF status + antiCCP antibody status + presence of radiographic changes at inclusion (n = 344).
 Model 4 (“metabolic + RA + steroid”): Model 3 + steroid prescription at inclusion (n = 344).
 The following variables were logtransformed: CRP level, HAQ score, serum adipokine levels.