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Table 1 Demographic, clinical and immunological characteristics of the patients a

From: Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity

Characteristics Total patients
(N = 107)
Matched patients
(N = 45)
Matched controls
(N = 45)
Age (years) 39.6 ± 14.1 46.7 ± 15.4 45.4 ± 15.9
Sex (F:M ratio) 3.9:1 3.1:1 3.1:1
Ethnicity    
Caucasian (%) 88.9 86.9 86.9
African (%) 6.7 6.5 6.5
Asian (%) 2.2 3.7 3.7
American Indian (%) 2.2 2.8 2.8
ACR total (number of criteria met) 5.51 ± 1.69 5.52 ± 1.69  
Antichromatin Ab 32.7 28.9  
Anti-dsDNA Ab (Crithidia luciliae test) (%) 27.1 33.3  
Anticardiolipin IgG Ab (%) 38.3 28.9  
LAC (%) 13.1 11.1  
Anti-Smith Ab (%) 18.7 11.1  
Anti-RNP Ab (%) 20.6 17.8  
Anti-Ro/SSA (Ro52/60 kDa) Ab (%) 38.3 (21.5/34.6) 31.1 (17.8/28.9)  
Anti-La/SSB (anti-Ro60 + anti-La) Ab (%) 16.8 (15.0) 15.6 (13.3)  
CH50 <40 (U/ml) 51.4 55.6  
C4 <16 (mg/dl) 35.5 44.4  
SLEDAI score 5.29 ± 4.20 5.02 ± 3.26  
Renal involvement (%) 13.1 24.4  
(BILAG grades A to C)
Mucocutaneous involvement (%) 68.2 57.8  
Musculoskeletal involvement (%) 77.6 66.7  
Cardiovascular/respiratory involvement (%) 14 15.6  
Hematological involvement (%) 37.4 31.1  
Vasculitis (%) 53.3 53.3  
Neurological involvement (%) 3.7 4.4  
BILAG total score 6.17 ± 4.53 5.70 ± 3.93  
Gas6 plasma levels (ng/ml) 18.81 ± 8.67 17.64 ± 7.10 15.89 ± 6.88
Free protein S plasma levels (μg/ml) 6.78 ± 2.36 6.37 ± 1.79 6.91 ± 1.74
  1. aAb, antibody; ACR total, number of American Rheumatism Association 1982 revised criteria for classification of systemic lupus erythematosus; BILAG, British Isles Lupus Assessment Group index; C4, complement fraction 4; CH50, 50% hemolytic complement activity of serum; dsDNA, double-stranded DNA; Gas6, growth arrest–specific 6; IgG, immunoglobulin G; LAC, lupus anticoagulant; RNP, ribonucleoprotein; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; SSA, Sjögren’s syndrome antigen A; SSB, Sjögren’s syndrome antigen B.