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Table 1 Description of patients and controls

From: Cartilage oligomeric matrix protein-induced complement activation in systemic sclerosis

  lcSSc baseline lcSSc second sample dcSSc baseline dcSSc second sample Controls
Number 40 40 40 40 97
Age, years median (range) 47.5 (16 to 77) 50 (21 to 81) 51.5 (22 to 77) 56 (26 to 80) 45 (23 to 74)
Gender, female:male 33:7 33:7 28:12 28:12 67:30
COMP, U/l median (range) 9.3 (4.2 to 27.9) 9.7 (3.9 to 15.8) 16.0 (6.2 to 37.2) 10.9 (5.0 to 30.0) 7.0 (3.2 to 12.1)
Disease duration, years median (range) 1.4 (0.2 to 3.0) 5.0 (3.2 to 7.1) 1.0 (0.3 to 3.0) 4.6 (3.3 to 7.5) Not applicable
COMP-C3b, AU median (range) 2.5 (0.4 to 6.4) 1.9 (0.8 to 6.1) 2.3 (0.2 to 3.8) 1.7 (0.7 to 4.0) 0.6 (0 to 4.4)
mRSS median (range) 5.0 (2.0 to 19.0) 3.0 (0 to 15.0) 22.5 (3.0 to 43.0) 12.5 (0 to 33.0) Not applicable
CRP, mg/l median (range) 5.0 (0.8 to 79.0) 4.0 (0 to 72.0) 9.9 (0.8 to 91.0) 4.9 (0.6 to 74.0) nd
ERS, mm/h median (range) 11.0 (2.0 to 92.0) 14.0 (3.0 to 60.0) 18.0 (4.0 to 50.5) 20.0 (2.0 to 66.0) nd
Immunosuppressant AZA:CYC:MTX:MMF 1:1:1:0 12:0:2:3 1:2:2:0 12:1:2:8  
Prednisolon, yes:no 7:32 11:28 13:25 13:25  
ANA, positive:negative 31:9   29:11   nd
ENA, positive:negative 10:30   10:30   nd
ACA, positive:negative 10:30   1:39   nd
ATA, positive:negative 3:32   7:29   nd
5 unknown 4 unknown
ARA, positive:negative 0:27   6:25   nd
13 unknown 9 unknown
  1. lcSSc, limited cutaneous systemic sclerosis; dcSSc, diffuse cutaneous systemic sclerosis; ACA, anti to centromere antibody; COMP: cartilage oligomeric matrix protein; AU, arbitrary units; mRSS, modified Rodnan skin score; CRP, C-reactive protein; nd, not determined; ERS, erythrocyte sedimentation rate; AZA, azathioprine; CYC, cyclophosphamide; MTX, methotrexate; MMF, mycophenolate mofetil; ANA, antinuclear antibody; ENA, extractable nuclear antigen antibody; ATA, anti-topoisomerase antibody; ARA, anti-RNA polymerase III antibody.