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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Deficient spontaneous in vitro apoptosis and increased tmTNF reverse signaling-induced apoptosis of monocytes predict suboptimal therapeutic response of rheumatoid arthritis to TNF inhibition

Figure 4

Monocytes with low spontaneous in vitr o apoptosis are susceptible for transmembrane TNF reverse signaling-induced apoptosis (tmTNF RSA). (A) Dot plot shows the rate of spontaneous in vitro apoptosis (SIA) in relation to tmTNF RSA) in rheumatoid arthritis (RA) patients (n = 20). tmTNF RSA is shown as ratio of TNFR2:Ig apoptosis and SIA. Regression coefficient and level of significance for the linear regression are as indicated. (B) Box plot depicts the rate of tmTNF RSA (light gray bars, TNFR2:Ig) in comparison to SIA (dark gray bars, IgG) in the groups with high and low tmTNF RSA separately (n = 20). Significant differences are as indicated. (C) Representative dot plots of annexin V- and propidium iodide-stained monocytes from one patient with high tmTNF RSA (left panels) and one with low TNF RSA (right panels). Upper panels show SIA (IgG), lower panels TNF RSA (TNFR2:Ig).

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